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Identifying Cancers Impacted by CDK8/19.
Roninson IB, Győrffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV. Roninson IB, et al. Among authors: mack zt. Cells. 2019 Aug 3;8(8):821. doi: 10.3390/cells8080821. Cells. 2019. PMID: 31382571 Free PMC article.
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Ding X, et al. Among authors: mack zt. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119. doi: 10.1073/pnas.2201073119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914167 Free PMC article.
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Cui BC, Sikirzhytski V, Aksenova M, Lucius MD, Levon GH, Mack ZT, Pollack C, Odhiambo D, Broude E, Lizarraga SB, Wyatt MD, Shtutman M. Cui BC, et al. Among authors: mack zt. Biochem Pharmacol. 2020 Dec;182:114280. doi: 10.1016/j.bcp.2020.114280. Epub 2020 Oct 10. Biochem Pharmacol. 2020. PMID: 33049245 Free PMC article.
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
Li J, Hilimire TA, Yueying L, Wang L, Liang J, Győrffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. Li J, et al. Among authors: mack zt. J Clin Invest. 2024 Mar 28:e176709. doi: 10.1172/JCI176709. Online ahead of print. J Clin Invest. 2024. PMID: 38546787 Free article.