An Overview of Currently Available Antimalarials

Curr Top Med Chem. 2017;17(19):2143-2157. doi: 10.2174/1568026617666170130123520.

Abstract

Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health.

Objective: Overview of currently available antimalarials.

Method: Literary survey.

Results: The summarized data about different types of antimalarial therapies and their efficiency and modes of action.

Conclusion: Despite the seemingly large number of the drugs currently available for malaria treatment, this arsenal is limited due to the narrow variation of their mechanism of action.

Keywords: Antimalarial drugs; Antimalarial therapy; Drug resistance; Malaria; Mechanism of action; Plasmodium.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Antimalarials / therapeutic use
  • Life Cycle Stages
  • Malaria / drug therapy
  • Malaria / prevention & control
  • Malaria Vaccines / administration & dosage
  • Plasmodium / drug effects*
  • Plasmodium / physiology

Substances

  • Antimalarials
  • Malaria Vaccines