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Page 1
Showing results for yangxu gong
Search for Yongxi Gong instead (3 results)
KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
Na F, Pan X, Chen J, Chen X, Wang M, Chi P, You L, Zhang L, Zhong A, Zhao L, Dai S, Zhang M, Wang Y, Wang B, Zheng J, Wang Y, Xu J, Wang J, Wu B, Chen M, Liu H, Xue J, Huang M, Gong Y, Zhu J, Zhou L, Zhang Y, Yu M, Tian P, Fan M, Lu Z, Xue Z, Zhao Y, Yang H, Zhao C, Wang Y, Han J, Yang S, Xie D, Chen L, Zhong Q, Zeng M, Lowe SW, Lu Y, Liu Y, Wei Y, Chen C. Na F, et al. Nat Cancer. 2022 Jun;3(6):753-767. doi: 10.1038/s43018-022-00361-6. Epub 2022 Apr 21. Nat Cancer. 2022. PMID: 35449309 Free PMC article.
To understand the molecular mechanisms underlying SCLC metastasis, we generated SCLC mouse models with orthotopically transplanted genome-edited lung organoids and performed multiomics analyses. We found that a deficiency of KMT2C, a histone H3 lysine 4 methyltransferase f …
To understand the molecular mechanisms underlying SCLC metastasis, we generated SCLC mouse models with orthotopically transplanted genome-ed …
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification.
Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. Yang L, et al. Circ Res. 2022 Jan 21;130(2):213-229. doi: 10.1161/CIRCRESAHA.121.319745. Epub 2021 Dec 6. Circ Res. 2022. PMID: 34870453
In contrast, XBP1u overexpression in high phosphate-induced vascular smooth muscle cells significantly inhibited osteogenic differentiation and calcification. Consistently, smooth muscle cell-specific XBP1 deficiency in mice markedly aggravated the adenine diet- and 5/6 ne …
In contrast, XBP1u overexpression in high phosphate-induced vascular smooth muscle cells significantly inhibited osteogenic differentiation …
Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation.
Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A. Shen W, et al. Cell. 2022 Dec 22;185(26):4954-4970.e20. doi: 10.1016/j.cell.2022.11.011. Epub 2022 Dec 8. Cell. 2022. PMID: 36493774 Free article.
Maternal transcription factors (TFs) transport into nuclei more efficiently with increasing CNM. Deficiency or dysfunction of Nup133 or Ahctf1/Elys impairs NPC assembly, maternal TFs nuclear transport, and ZGA onset, while nup133 overexpression promotes these processes. .. …
Maternal transcription factors (TFs) transport into nuclei more efficiently with increasing CNM. Deficiency or dysfunction of Nup133 …
CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.
Gong Z, Zhu J, Chen J, Feng F, Zhang H, Zhang Z, Song C, Liang K, Yang S, Fan S, Fang X, Shen S. Gong Z, et al. Nat Commun. 2023 Aug 28;14(1):5242. doi: 10.1038/s41467-023-40975-7. Nat Commun. 2023. PMID: 37640697 Free PMC article.
Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes and its deficiency can alleviate FASN related senescent phenotypes and osteoarthritis progression. ...Intra-articular injection of adenovirus-CircRreb1 reverses the protective effect …
Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes and its deficiency can alleviate FASN rela …
TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53.
Gong S, Zhai M, Shi J, Yu G, Lei Z, Shi Y, Zeng Y, Ju P, Yang N, Zhang Z, Zhang D, Zhuang J, Yu Q, Zhang X, Jian W, Wang W, Peng W. Gong S, et al. Cell Death Differ. 2024 Feb;31(2):239-253. doi: 10.1038/s41418-023-01252-8. Epub 2024 Jan 5. Cell Death Differ. 2024. PMID: 38182899 Free PMC article.
TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myocardial infarction remains unclear. In this study, we showed that macrophage-specific TREM2 deficiency worsened cardiac function and impaired post-MI repair. Using RNA-seq, protein …
TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myocardial infarction remains unclear. In this stu …
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z, Bai X. Gong Y, et al. Dev Cell. 2023 Feb 6;58(3):192-210.e11. doi: 10.1016/j.devcel.2022.12.012. Epub 2023 Jan 24. Dev Cell. 2023. PMID: 36696903 Free article.
Here, we show that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which is associated with a high rate of chromothripsis. In rapidly expanding mouse osteoprogenitors, RanGAP1 deficiency causes chromothripsis in …
Here, we show that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which is as …
CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation.
Yang L, Li N, Yang D, Chen A, Tang J, Jing Y, Kang D, Jiang P, Dai X, Luo L, Chen Q, Chang J, Liu J, Gu H, Huang Y, Chen Q, Li Z, Zhu Y, Miller H, Chen Y, Qiu L, Mei H, Hu Y, Gong Q, Liu C. Yang L, et al. Cell Death Differ. 2021 Sep;28(9):2616-2633. doi: 10.1038/s41418-021-00775-2. Epub 2021 Apr 20. Cell Death Differ. 2021. PMID: 33879857 Free PMC article.
Nevertheless, the intrinsic role of CCL2 on B-cell autoimmunity is unknown. In this study using Ccl2 KO mice, we found that CCL2 deficiency enhanced BCR signaling by upregulating the phosphorylation of the MST1-mTORC1-STAT1 axis, which led to reduced marginal zone (MZ) B c …
Nevertheless, the intrinsic role of CCL2 on B-cell autoimmunity is unknown. In this study using Ccl2 KO mice, we found that CCL2 deficien …
Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension.
Shen Y, Dong Z, Fan F, Li K, Zhu S, Dai R, Huang J, Xie N, He L, Gong Z, Yang X, Tan J, Liu L, Yu F, Tang Y, You Z, Xi J, Wang Y, Kong W, Zhang Y, Fu Y. Shen Y, et al. Cell Rep Med. 2023 Jun 20;4(6):101072. doi: 10.1016/j.xcrm.2023.101072. Epub 2023 Jun 9. Cell Rep Med. 2023. PMID: 37301198 Free PMC article.
A case-control study exhibits that FAM3D is elevated in patients with hypertension, with a positive association with odds of hypertension. FAM3D deficiency significantly ameliorates angiotensin II (AngII)-induced hypertension in mice. Mechanistically, FAM3D directly causes …
A case-control study exhibits that FAM3D is elevated in patients with hypertension, with a positive association with odds of hypertension. F …
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
Li Y, Huang D, Jia L, Shangguan F, Gong S, Lan L, Song Z, Xu J, Yan C, Chen T, Tan Y, Liu Y, Huang X, Suzuki CK, Yang Z, Yang G, Lu B. Li Y, et al. Research (Wash D C). 2023 Jun 16;6:0175. doi: 10.34133/research.0175. eCollection 2023. Research (Wash D C). 2023. PMID: 37333972 Free PMC article.
Furthermore, deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER (UPR(ER)). Consequently, cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming a …
Furthermore, deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolde …
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Kraus D, et al. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. Nature. 2014. PMID: 24717514 Free PMC article.
268 results