A highly sensitive and selective bis(salamo)-type fluorescent chemosensor for identification of Cu²⁺ and the continuous recognition of S^2-, Arginine and Lysine

A novel bis(salamo)-type chemosensor H₃L was synthesized and characterized. It was found that the sensor molecule can selectively recognize Cu²⁺, and its L-Cu²⁺ is highly sensitive to the detection of S^2- anion, Arginine and Lysine when dissolved in ethanol solvent. The sensor H₃L can be used to identify a relay sensor for Cu²⁺, while the L-Cu²⁺ recognizes S^2- anion, Arginine and Lysine with high selectivity and sensitivity over an acceptable physiological pH range. The detection line of the sensor molecule H₃L is 1.02 × 10^-6 M, and its binding constant to Cu²⁺ is 1.54 × 10⁶ M^-1. The detection line of L-Cu²⁺ as a sensor is calculated as 5.57 × 10^-7 M, and its binding constants with S^2- anion, Arginine and Lysine are 2.80 × 10⁵ M^-1, 5.32 × 10⁶ M^-1 and 5.94 × 10⁶ M^-1, respectively. The crystal structure of the Cu(II) complex [Cu₄(L)₂(CH₃OH)₂]·2NO₃ with the sensor molecule H₃L has been determined by single crystal X-ray crystallography.