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Showing results for yan qin pan
Search for Yanqin Pan instead (1 results)
Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis.
Qin Y, Liu Y, Xiang X, Long X, Chen Z, Huang X, Yang J, Li W. Qin Y, et al. Mol Cancer. 2023 Mar 24;22(1):59. doi: 10.1186/s12943-023-01752-8. Mol Cancer. 2023. PMID: 36959665 Free PMC article.
In the present study, we comprehensively analyzed the expression difference, gene variation and methylation modification of cuproptosis-related genes (CRGs) in pan-cancer. Then, Single sample gene set enrichment analysis (ssGSEA) was used to calculate individual cuproptosi …
In the present study, we comprehensively analyzed the expression difference, gene variation and methylation modification of cuproptosis-rela …
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Wei J, et al. Among authors: yan q. Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20. Cell. 2021. PMID: 33147444 Free PMC article.
We additionally discovered pro-viral genes and pathways, including HMGB1 and the SWI/SNF chromatin remodeling complex, that are SARS lineage and pan-coronavirus specific, respectively. We show that HMGB1 regulates ACE2 expression and is critical for entry of SARS-CoV-2, SA …
We additionally discovered pro-viral genes and pathways, including HMGB1 and the SWI/SNF chromatin remodeling complex, that are SARS lineage …
Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation.
Qin Y, Yang J, Liang C, Liu J, Deng Z, Yan B, Fu Y, Luo Y, Li X, Wei X, Li W. Qin Y, et al. Front Immunol. 2022 Nov 3;13:994828. doi: 10.3389/fimmu.2022.994828. eCollection 2022. Front Immunol. 2022. PMID: 36405728 Free PMC article.
Additionally, the migrasome scores were significantly correlated with the immune checkpoint genes in pan-cancer as well as immune checkpoint therapy-related markers including TMB and MSI. ...IHC confirmed low expression of ITGA5 and PIGK in colorectal cancer. DISCUSSION: W …
Additionally, the migrasome scores were significantly correlated with the immune checkpoint genes in pan-cancer as well as immune che …
NAT10-dependent N(4)-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation.
Yan Q, Zhou J, Wang Z, Ding X, Ma X, Li W, Jia X, Gao SJ, Lu C. Yan Q, et al. Nat Commun. 2023 Oct 10;14(1):6327. doi: 10.1038/s41467-023-42135-3. Nat Commun. 2023. PMID: 37816771 Free PMC article.
Mutagenesis of ac(4)C sites in PAN RNA in the context of KSHV infection abolishes PAN ac(4)C modifications, downregulates the expression of viral lytic genes and reduces virion production. NAT10 knockdown or mutagenesis erases ac(4)C modifications of PAN RNA …
Mutagenesis of ac(4)C sites in PAN RNA in the context of KSHV infection abolishes PAN ac(4)C modifications, downregulates the …
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.
Wei J, Alfajaro MM, Cai WL, Graziano VR, Strine MS, Filler RB, Biering SB, Sarnik SA, Patel S, Menasche BL, Compton SR, Konermann S, Hsu PD, Orchard RC, Yan Q, Wilen CB. Wei J, et al. Among authors: yan q. PLoS Pathog. 2023 Jul 6;19(7):e1011351. doi: 10.1371/journal.ppat.1011351. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37410700 Free PMC article.
These data highlight the role for KDM6A-KMT2D-p300 complex activities in conferring diverse coronaviruses susceptibility and reveal a potential pan-coronavirus therapeutic target to combat current and emerging coronaviruses. ...
These data highlight the role for KDM6A-KMT2D-p300 complex activities in conferring diverse coronaviruses susceptibility and reveal a potent …
Pan-cancer analysis of IFN-gamma with possible immunotherapeutic significance: a verification of single-cell sequencing and bulk omics research.
Wei X, Ruan H, Zhang Y, Qin T, Zhang Y, Qin Y, Li W. Wei X, et al. Among authors: qin y. Front Immunol. 2023 Aug 14;14:1202150. doi: 10.3389/fimmu.2023.1202150. eCollection 2023. Front Immunol. 2023. PMID: 37646041 Free PMC article.
Previous studies have discussed the role and mechanisms associated with IFN-gamma in specific tumors or diseases, but the relevant role of IFN-gamma in pan-cancer remains uncertain. METHODS: TCGA and GTEx RNA expression data and clinical data were downloaded. ...
Previous studies have discussed the role and mechanisms associated with IFN-gamma in specific tumors or diseases, but the relevant role of I …
Immunological role and prognostic potential of CLEC10A in pan-cancer.
Qin Y, Wang L, Zhang L, Li J, Liao L, Huang L, Li W, Yang J. Qin Y, et al. Am J Transl Res. 2022 May 15;14(5):2844-2860. eCollection 2022. Am J Transl Res. 2022. PMID: 35702069 Free PMC article.
OBJECTIVES: CLEC10A is expressed in a variety of cells, involved in a variety of biological pathways including immune response, and is closely related to the development of tumor immune response. However, the role of CLEC10A from a pan-cancer perspective has not yet been a …
OBJECTIVES: CLEC10A is expressed in a variety of cells, involved in a variety of biological pathways including immune response, and is close …
Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation.
Qin Y, Pan L, Qin T, Ruan H, Zhang Y, Zhang Y, Li J, Yang J, Li W. Qin Y, et al. Front Immunol. 2022 Sep 29;13:998266. doi: 10.3389/fimmu.2022.998266. eCollection 2022. Front Immunol. 2022. PMID: 36248785 Free PMC article.
However, there have been fewer studies on AIM2 inflammasomes in pan-cancer. METHODS: Gene expression was analyzed using The Cancer Genome Atlas (TCGA) database and The Genotype-Tissue Expression (GTEx) database. ...We used the survival curve to explore the prognostic signi …
However, there have been fewer studies on AIM2 inflammasomes in pan-cancer. METHODS: Gene expression was analyzed using The Cancer Ge …
29 results