Syntheses and biological activities of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

Jian-yu Jin; Li-xue Zhang; Xian-xing Chen; An-jiang Zhang; Hai-le Zhang

doi:10.3390/12030297

Syntheses and biological activities of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

Molecules. 2007 Mar 3;12(3):297-303. doi: 10.3390/12030297.

Authors

Jian-yu Jin¹, Li-xue Zhang, Xian-xing Chen, An-jiang Zhang, Hai-le Zhang

Affiliation

¹ College of Education, Wenzhou University, Wenzhou 325035, P.R. China.

Abstract

A series of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]-thiadiazines were synthesized by the reaction of 4-amino-3-(3-hydroxypropyl)-5-mercapto-1,2,4-triazole (1) with substituted omega-haloacetophenones. Their structures were confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR. Tests of plant growth regulating effects showed that the title compounds display remarkable inhibitory activities on the growth of radish and wheat.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon Isotopes
Germination / drug effects
Magnetic Resonance Spectroscopy
Plant Growth Regulators / pharmacology
Plant Roots / drug effects
Plant Shoots / drug effects
Raphanus / drug effects
Spectrophotometry, Infrared
Thiadiazines / chemical synthesis*
Thiadiazines / chemistry
Thiadiazines / metabolism*
Thiadiazines / pharmacology
Triazoles / chemical synthesis*
Triazoles / chemistry
Triazoles / metabolism*
Triazoles / pharmacology
Triticum / drug effects

Substances

Carbon Isotopes
Plant Growth Regulators
Thiadiazines
Triazoles