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Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Kousathanas A, et al. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Nature. 2022. PMID: 35255492 Free PMC article.
A saturated map of common genetic variants associated with human height.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lüll K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rüeger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Cañadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, He J, Heard-Costa N, … See abstract for full author list ➔ Yengo L, et al. Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. Nature. 2022. PMID: 36224396 Free PMC article.
An Integrative Tinnitus Model Based on Sensory Precision.
Sedley W, Friston KJ, Gander PE, Kumar S, Griffiths TD. Sedley W, et al. Trends Neurosci. 2016 Dec;39(12):799-812. doi: 10.1016/j.tins.2016.10.004. Epub 2016 Nov 18. Trends Neurosci. 2016. PMID: 27871729 Free PMC article. Review.
Extant models feature as contributory mechanisms acting to increase either the intensity of the precursor or its precision. If precision (i.e., postsynaptic gain) rises sufficiently then tinnitus is perceived. ...
Extant models feature as contributory mechanisms acting to increase either the intensity of the precursor or its precision. If precision (i. …
Associations of autozygosity with a broad range of human phenotypes.
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, … See abstract for full author list ➔ Clark DW, et al. Nat Commun. 2019 Oct 31;10(1):4957. doi: 10.1038/s41467-019-12283-6. Nat Commun. 2019. PMID: 31673082 Free PMC article.
Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids.
Griffiths WJ. Griffiths WJ. Mass Spectrom Rev. 2003 Mar-Apr;22(2):81-152. doi: 10.1002/mas.10046. Mass Spectrom Rev. 2003. PMID: 12820273 Review.
Since the early 1970s, there have been three outstanding developments in mass spectrometry that are particularly appropriate in lipid analysis; i.e., the introduction of (i) fast atom bombardment (FAB); (ii) electrospray (ES); and (iii) tandem mass spectrometry (MS/MS). .. …
Since the early 1970s, there have been three outstanding developments in mass spectrometry that are particularly appropriate in lipid analys …
Diving into the vertical dimension of elasmobranch movement ecology.
Andrzejaczek S, Lucas TCD, Goodman MC, Hussey NE, Armstrong AJ, Carlisle A, Coffey DM, Gleiss AC, Huveneers C, Jacoby DMP, Meekan MG, Mourier J, Peel LR, Abrantes K, Afonso AS, Ajemian MJ, Anderson BN, Anderson SD, Araujo G, Armstrong AO, Bach P, Barnett A, Bennett MB, Bezerra NA, Bonfil R, Boustany AM, Bowlby HD, Branco I, Braun CD, Brooks EJ, Brown J, Burke PJ, Butcher P, Castleton M, Chapple TK, Chateau O, Clarke M, Coelho R, Cortes E, Couturier LIE, Cowley PD, Croll DA, Cuevas JM, Curtis TH, Dagorn L, Dale JJ, Daly R, Dewar H, Doherty PD, Domingo A, Dove ADM, Drew M, Dudgeon CL, Duffy CAJ, Elliott RG, Ellis JR, Erdmann MV, Farrugia TJ, Ferreira LC, Ferretti F, Filmalter JD, Finucci B, Fischer C, Fitzpatrick R, Forget F, Forsberg K, Francis MP, Franks BR, Gallagher AJ, Galvan-Magana F, García ML, Gaston TF, Gillanders BM, Gollock MJ, Green JR, Green S, Griffiths CA, Hammerschlag N, Hasan A, Hawkes LA, Hazin F, Heard M, Hearn A, Hedges KJ, Henderson SM, Holdsworth J, Holland KN, Howey LA, Hueter RE, Humphries NE, Hutchinson M, Jaine FRA, Jorgensen SJ, Kanive PE, Labaja J, Lana FO, Lassauce H, Lipscombe RS, Llewellyn F, Macena BCL, Mambrasar R, McAllister JD, McCully Phillips SR,… See abstract for full author list ➔ Andrzejaczek S, et al. Sci Adv. 2022 Aug 19;8(33):eabo1754. doi: 10.1126/sciadv.abo1754. Epub 2022 Aug 19. Sci Adv. 2022. PMID: 35984887 Free PMC article.
Thick shells and medially wedged posts increase foot orthoses medial longitudinal arch stiffness: an experimental study.
Pelaez AST, Farahpour N, Griffiths IB, Moisan G. Pelaez AST, et al. J Foot Ankle Res. 2023 Mar 3;16(1):11. doi: 10.1186/s13047-023-00609-z. J Foot Ankle Res. 2023. PMID: 36869383 Free PMC article.
Preliminary results suggest that adding extrinsic additions to FOs (e.g., rearfoot posts) increases their medial arch stiffness. A better understanding of how FOs medial arch stiffness can be modulated by changing structural factors is necessary to better customise FOs for …
Preliminary results suggest that adding extrinsic additions to FOs (e.g., rearfoot posts) increases their medial arch stiffness. A be …
Defining trajectories of response in patients with psoriasis treated with biologic therapies.
Geifman N, Azadbakht N, Zeng J, Wilkinson T, Dand N, Buchan I, Stocken D, Di Meglio P, Warren RB, Barker JN, Reynolds NJ, Barnes MR, Smith CH, Griffiths CEM, Peek N; BADBIR Study Group, on behalf of the PSORT Consortium. Geifman N, et al. Br J Dermatol. 2021 Oct;185(4):825-835. doi: 10.1111/bjd.20140. Epub 2021 Jun 4. Br J Dermatol. 2021. PMID: 33829489
Each class was associated with differing clinical characteristics, e.g. body mass index, baseline PASI and prevalence of different manifestations. ...
Each class was associated with differing clinical characteristics, e.g. body mass index, baseline PASI and prevalence of different ma …
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis.
Andres-Ejarque R, Ale HB, Grys K, Tosi I, Solanky S, Ainali C, Catak Z, Sreeneebus H, Saklatvala J, Dand N, de Rinaldis E, Chapman A, Nestle FO, Barnes MR, Warren RB, Reynolds NJ, Griffiths CEM, Barker JN, Smith CH, Di Meglio P; PSORT Consortium. Andres-Ejarque R, et al. Nat Commun. 2021 Aug 6;12(1):4741. doi: 10.1038/s41467-021-25066-9. Nat Commun. 2021. PMID: 34362923 Free PMC article.
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.
Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, Pirmohamed M; PSORT Consortium; Anders S, Reynolds NJ, Griffiths CEM, Warren RB, Barnes MR. Foulkes AC, et al. J Invest Dermatol. 2019 Jan;139(1):100-107. doi: 10.1016/j.jid.2018.04.041. Epub 2018 Jul 17. J Invest Dermatol. 2019. PMID: 30030151 Free PMC article.
To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) study, we evaluated a comprehensive array of omics platforms across three time points and multiple tissues in a pilot investigation of 10 patients with severe psoriasis …
To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) study, we evaluated a compre …
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