Using the 150 rule to prevent hepatotoxicity from acetaminophen

JAAPA. 2019 Apr;32(4):51-53. doi: 10.1097/01.JAA.0000554235.40113.c5.

Abstract

Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure in adults and a major cause of acute liver failure in children. Prompt treatment with N-acetylcysteine can mitigate hepatotoxicity and progression to liver failure. This article describes a 16-year-old girl who ingested a large dose of extra-strength acetaminophen, and how the 150 rule was used in her management.

Publication types

  • Case Reports

MeSH terms

  • Acetaminophen / adverse effects*
  • Acetaminophen / pharmacokinetics
  • Acetaminophen / toxicity*
  • Acetylcysteine / administration & dosage
  • Acetylcysteine / therapeutic use
  • Adolescent
  • Diagnosis, Differential
  • Disease Progression
  • Drug Overdose / diagnosis*
  • Drug Overdose / etiology*
  • Female
  • Humans
  • Liver Failure, Acute / chemically induced*
  • Liver Failure, Acute / drug therapy
  • Liver Failure, Acute / prevention & control*

Substances

  • Acetaminophen
  • Acetylcysteine