Abstract
Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure in adults and a major cause of acute liver failure in children. Prompt treatment with N-acetylcysteine can mitigate hepatotoxicity and progression to liver failure. This article describes a 16-year-old girl who ingested a large dose of extra-strength acetaminophen, and how the 150 rule was used in her management.
MeSH terms
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Acetaminophen / adverse effects*
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Acetaminophen / pharmacokinetics
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Acetaminophen / toxicity*
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Acetylcysteine / administration & dosage
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Acetylcysteine / therapeutic use
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Adolescent
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Diagnosis, Differential
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Disease Progression
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Drug Overdose / diagnosis*
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Drug Overdose / etiology*
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Female
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Humans
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Liver Failure, Acute / chemically induced*
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Liver Failure, Acute / drug therapy
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Liver Failure, Acute / prevention & control*
Substances
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Acetaminophen
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Acetylcysteine