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Development and validation of risk calculators for people with "thin" melanomas on their skin to predict the likelihood that their cancer will return: a plain language summary of publication.
Sharouni ME, Lo SN, Varey AH, Elias SG, Witkamp AJ, Sigurdsson V, Suijkerbuijk KP, van Diest PJ, van Gils CH, Blokx WA, Scolyer RA, Thompson JF. Sharouni ME, et al. Future Oncol. 2023 Jan;19(2):97-102. doi: 10.2217/fon-2022-0525. Epub 2023 Feb 10. Future Oncol. 2023. PMID: 36762595 Free article. Review.
This is a summary of an article describing the development of risk calculators for use in people who develop a type of melanoma on their skin called "thin" melanoma to predict the likelihood that their cancer will return. The article was originally published in the Journal …
This is a summary of an article describing the development of risk calculators for use in people who develop a type of melanoma on their ski …
Has the advent of modern adjuvant systemic therapy for melanoma rendered sentinel node biopsy unnecessary?
Varey AHR, Thompson JF, Howle JR, Lo SN, Ch'ng S, Carlino MS. Varey AHR, et al. Eur J Cancer. 2023 Jun;186:166-171. doi: 10.1016/j.ejca.2023.03.011. Epub 2023 Mar 17. Eur J Cancer. 2023. PMID: 37080117
However, since the Keynote 716 trial demonstrated an improvement in relapse-free survival (RFS) in patients with Stage IIB/C melanoma, all of whom had SNB staging, some have argued that SNB is no longer required for patients with T3 and T4 primary melanomas. The rationale for omi …
However, since the Keynote 716 trial demonstrated an improvement in relapse-free survival (RFS) in patients with Stage IIB/C melanoma, all o …
Predicting Recurrence-Free and Overall Survival for Patients With Stage II Melanoma: The MIA Calculator.
Varey AHR, Li I, El Sharouni MA, Simon J, Dedeilia A, Ch'ng S, Saw RPM, Spillane AJ, Shannon KF, Pennington TE, Rtshiladze M, Stretch JR, Nieweg OE, van Akkooi A, Sullivan RJ, Boland GM, Gershenwald JE, van Diest PJ, Scolyer RA, Long GV, Thompson JF, Lo SN. Varey AHR, et al. J Clin Oncol. 2024 Apr 1;42(10):1169-1180. doi: 10.1200/JCO.23.01020. Epub 2024 Feb 5. J Clin Oncol. 2024. PMID: 38315961
These models were robust on external validations and may be used in everyday practice both with (ideally) and without performing SN biopsy to identify high-risk patients for further management strategies. An online tool will be available at the MIA website (Risk Prediction …
These models were robust on external validations and may be used in everyday practice both with (ideally) and without performing SN biopsy t …
Developing and evaluating online COVID-centric advance care planning training and information resources for nursing staff and family members in nursing homes: the necessary discussions study protocol.
Harding A, Preston N, Doherty J, Cousins E, Varey S, McCann A, Dening KH, Finucane A, Carter G, Mitchell G, Brazil K. Harding A, et al. BMC Geriatr. 2021 Aug 9;21(1):456. doi: 10.1186/s12877-021-02398-1. BMC Geriatr. 2021. PMID: 34372794 Free PMC article.
To evaluate the resources, we will employ a multiple case study design where a nursing home (defined as an institutional setting in which nursing care is provided to older adults on-site 24 h a day) will be the unit of analysis or 'case'. ...It meets a key need and …
To evaluate the resources, we will employ a multiple case study design where a nursing home (defined as an institutional setting in w …
Cell therapy using tolerogenic dendritic cells in transplantation.
Moreau A, Varey E, Bouchet-Delbos L, Cuturi MC. Moreau A, et al. Transplant Res. 2012 Sep 28;1(1):13. doi: 10.1186/2047-1440-1-13. Transplant Res. 2012. PMID: 23369513 Free PMC article.
Proof of safety of TolDC therapy in the clinic has already been demonstrated in patients with diabetes. However, in transplantation, DC therapy will be associated with the administration of immunosuppressive drugs, and interactions between drugs and DC are possible. Finall …
Proof of safety of TolDC therapy in the clinic has already been demonstrated in patients with diabetes. However, in transplantation, DC ther …
Predicting sentinel node positivity in patients with melanoma: external validation of a risk-prediction calculator (the Melanoma Institute Australia nomogram) using a large European population-based patient cohort.
El Sharouni MA, Varey AHR, Witkamp AJ, Ahmed T, Sigurdsson V, van Diest PJ, Scolyer RA, Thompson JF, Lo SN, van Gils CH. El Sharouni MA, et al. Br J Dermatol. 2021 Aug;185(2):412-418. doi: 10.1111/bjd.19895. Epub 2021 May 9. Br J Dermatol. 2021. PMID: 33657653
CONCLUSIONS: This population-based validation study in European patients with melanoma confirmed the value of the MIA nomogram in predicting SN positivity. Its use will spare low-risk patients the inconvenience, cost and potential risks of SN biopsy while ensuring that hig …
CONCLUSIONS: This population-based validation study in European patients with melanoma confirmed the value of the MIA nomogram in predicting …
How effective and cost-effective are innovative combinatorial technologies and practices for supporting older people with long-term conditions to remain well in the community? An evaluation protocol for an NHS Test Bed in North West England.
Varey S, Hernández A, Palmer TM, Mateus C, Wilkinson J, Dixon M, Milligan C. Varey S, et al. BMJ Open. 2018 Feb 28;8(2):e017268. doi: 10.1136/bmjopen-2017-017268. BMJ Open. 2018. PMID: 29490952 Free PMC article.
A health economic analysis of its costs and associated cost changes will be undertaken. Phase 2 data will be analysed thematically with the aid of Atlas.ti qualitative software. ...
A health economic analysis of its costs and associated cost changes will be undertaken. Phase 2 data will be analysed thematic …
Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials.
Moreau A, Varey E, Bériou G, Hill M, Bouchet-Delbos L, Segovia M, Cuturi MC. Moreau A, et al. Front Immunol. 2012 Aug 9;3:218. doi: 10.3389/fimmu.2012.00218. eCollection 2012. Front Immunol. 2012. PMID: 22908013 Free PMC article.
With the aim of using autologous DC in kidney transplant patients, we have developed and characterized tolerogenic monocyte-derived DC in humans. In this review, we will discuss the preclinical studies and describe our recent results from the generation and characterizatio …
With the aim of using autologous DC in kidney transplant patients, we have developed and characterized tolerogenic monocyte-derived DC in hu …
Poor Adherence to National Clinical Management Guidelines: A Population-Based, Cross-Sectional Study of the Surgical Management of Melanoma in New South Wales, Australia.
Varey AHR, Madronio CM, Cust AE, Goumas C, Mann GJ, Armstrong BK, Scolyer RA, Curtin AM, Thompson JF. Varey AHR, et al. Ann Surg Oncol. 2017 Aug;24(8):2080-2088. doi: 10.1245/s10434-017-5890-7. Epub 2017 May 25. Ann Surg Oncol. 2017. PMID: 28547563
The better concordance achieved by physicians treating >30 melanomas per year suggests that a minimum caseload threshold for physicians treating melanoma patients would be desirable. High guideline concordance will ensure patients receive optimal care and minimize morbi …
The better concordance achieved by physicians treating >30 melanomas per year suggests that a minimum caseload threshold for physicians t …
Factors predisposing to wrong blood in tube incidents: a year's experience in the North East of England.
Varey A, Tinegate H, Robertson J, Watson D, Iqbal A. Varey A, et al. Transfus Med. 2013 Oct;23(5):321-5. doi: 10.1111/tme.12050. Epub 2013 Jun 29. Transfus Med. 2013. PMID: 23808358
If our figures are representative of the whole of the UK, then over 1160 WBITs will occur each year, justifying SHOT's concerns that WBITs are under reported. ...
If our figures are representative of the whole of the UK, then over 1160 WBITs will occur each year, justifying SHOT's concerns that …