Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice.
Yang Q, Zuo Z, Zeng Y, Ouyang Y, Cui H, Deng H, Zhu Y, Deng J, Geng Y, Ouyang P, Lai W, Du Z, Ni X, Yin H, Fang J, Guo H.
Yang Q, et al.
Ecotoxicol Environ Saf. 2023 Jul 1;259:115049. doi: 10.1016/j.ecoenv.2023.115049. Epub 2023 May 24.
Ecotoxicol Environ Saf. 2023.
PMID: 37235900
Free article.
Moreover, NiCl(2) increased COX-2 protein levels, decreased SLC7A11 and GPX4 protein levels, and elevated Ptgs2 mRNA levels. Next, the mechanism of Ni-induced ferroptosis was investigated. The results showed that NiCl(2) induced autophagy in TCMK-1 cells, which promoted fe …
Moreover, NiCl(2) increased COX-2 protein levels, decreased SLC7A11 and GPX4 protein levels, and elevated Ptgs2 mRNA levels. Next, the mecha …