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Page 1
A common mechanism of Sec61 translocon inhibition by small molecules.
Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, Shi WQ, Forsyth C, Hoepfner D, Spiess M, Park E. Itskanov S, et al. Among authors: shi wq. Nat Chem Biol. 2023 Sep;19(9):1063-1071. doi: 10.1038/s41589-023-01337-y. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169959
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. Among authors: shi wq. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.
Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F.
Zong G, Hu Z, Duah KB, Andrews LE, Zhou J, O'Keefe S, Whisenhunt L, Shim JS, Du Y, High S, Shi WQ. Zong G, et al. Among authors: shi wq. J Org Chem. 2020 Dec 18;85(24):16226-16235. doi: 10.1021/acs.joc.0c01659. Epub 2020 Dec 2. J Org Chem. 2020. PMID: 33264019 Free PMC article.
25 results