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Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
J Med Chem. 2021 Aug 26;64(16):12322-12358. doi: 10.1021/acs.jmedchem.1c01002. Epub 2021 Aug 11.
J Med Chem. 2021.
PMID: 34378914
New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain.
Klein P, Johe P, Wagner A, Jung S, Kühlborn J, Barthels F, Tenzer S, Distler U, Waigel W, Engels B, Hellmich UA, Opatz T, Schirmeister T.
Klein P, et al. Among authors: waigel w.
Molecules. 2020 Mar 23;25(6):1451. doi: 10.3390/molecules25061451.
Molecules. 2020.
PMID: 32210166
Free PMC article.
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Library of Azabenz-Annulated Core-Extended Perylene Derivatives with Diverse Substitution Patterns and Tunable Electronic and Optical Properties.
Schulze M, Philipp M, Waigel W, Schmidt D, Würthner F.
Schulze M, et al. Among authors: waigel w.
J Org Chem. 2016 Sep 16;81(18):8394-405. doi: 10.1021/acs.joc.6b01573. Epub 2016 Aug 29.
J Org Chem. 2016.
PMID: 27568658
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