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De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry.
Passioura T, Watashi K, Fukano K, Shimura S, Saso W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami M, Sureau C, Suga H, Wakita T. Passioura T, et al. Among authors: saso w. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5. doi: 10.1016/j.chembiol.2018.04.011. Epub 2018 May 17. Cell Chem Biol. 2018. PMID: 29779957 Free article.
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment.
Ohashi H, Watashi K, Saso W, Shionoya K, Iwanami S, Hirokawa T, Shirai T, Kanaya S, Ito Y, Kim KS, Nomura T, Suzuki T, Nishioka K, Ando S, Ejima K, Koizumi Y, Tanaka T, Aoki S, Kuramochi K, Suzuki T, Hashiguchi T, Maenaka K, Matano T, Muramatsu M, Saijo M, Aihara K, Iwami S, Takeda M, McKeating JA, Wakita T. Ohashi H, et al. Among authors: saso w. iScience. 2021 Apr 23;24(4):102367. doi: 10.1016/j.isci.2021.102367. Epub 2021 Mar 26. iScience. 2021. PMID: 33817567 Free PMC article.
Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro.
Ohashi H, Wang F, Stappenbeck F, Tsuchimoto K, Kobayashi C, Saso W, Kataoka M, Yamasaki M, Kuramochi K, Muramatsu M, Suzuki T, Sureau C, Takeda M, Wakita T, Parhami F, Watashi K. Ohashi H, et al. Among authors: saso w. Int J Mol Sci. 2021 Mar 19;22(6):3163. doi: 10.3390/ijms22063163. Int J Mol Sci. 2021. PMID: 33808940 Free PMC article.
Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.
Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Sureau C, Wakita T, Watashi K. Iwamoto M, et al. Among authors: saso w. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5. Proc Natl Acad Sci U S A. 2019. PMID: 30952782 Free PMC article.
Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro.
Shionoya K, Yamasaki M, Iwanami S, Ito Y, Fukushi S, Ohashi H, Saso W, Tanaka T, Aoki S, Kuramochi K, Iwami S, Takahashi Y, Suzuki T, Muramatsu M, Takeda M, Wakita T, Watashi K. Shionoya K, et al. Among authors: saso w. Front Microbiol. 2021 Apr 30;12:651403. doi: 10.3389/fmicb.2021.651403. eCollection 2021. Front Microbiol. 2021. PMID: 33995308 Free PMC article.
Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.
Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K. Kaneko M, et al. Among authors: saso w. Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w. Sci Rep. 2018. PMID: 29426822 Free PMC article.
The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network.
Iwamoto M, Saso W, Nishioka K, Ohashi H, Sugiyama R, Ryo A, Ohki M, Yun JH, Park SY, Ohshima T, Suzuki R, Aizaki H, Muramatsu M, Matano T, Iwami S, Sureau C, Wakita T, Watashi K. Iwamoto M, et al. Among authors: saso w. J Biol Chem. 2020 Jan 17;295(3):800-807. doi: 10.1074/jbc.AC119.010366. Epub 2019 Dec 12. J Biol Chem. 2020. PMID: 31836663 Free PMC article.
A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.
Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K. Saso W, et al. Biochem Biophys Res Commun. 2018 Jun 22;501(2):374-379. doi: 10.1016/j.bbrc.2018.04.187. Epub 2018 May 11. Biochem Biophys Res Commun. 2018. PMID: 29730285