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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.
Machado DE, Perini JA, de Mendonça EM, Branco JR, Rodrigues-Baptista KC, Alessandra-Perini J, Espíndola-Netto JM, Dos Santos TA, Coelho WS, Nasciutti LE, Sola-Penna M, Zancan P. Machado DE, et al. Among authors: coelho ws. Mol Cell Endocrinol. 2018 Nov 15;476:17-26. doi: 10.1016/j.mce.2018.04.005. Epub 2018 Apr 22. Mol Cell Endocrinol. 2018. PMID: 29689297 Free article.
Clotrimazole is effective, safe and tolerable for the treatment of endometriosis and functions by downregulating inducible nitric oxide synthase and modulating oxidative stress biomarkers.
Machado DE, Saggioro EM, Sales Junior SF, Alessandra-Perini J, de Campos Gomes Diniz L, Coelho WS, Zancan P, Perini JA. Machado DE, et al. Among authors: coelho ws. Mol Cell Endocrinol. 2023 Mar 15;564:111883. doi: 10.1016/j.mce.2023.111883. Epub 2023 Feb 2. Mol Cell Endocrinol. 2023. PMID: 36736881