Synthesis of New Cisplatin Derivatives from Bile Acids

Barbara Seroka; Zenon Łotowski; Agnieszka Hryniewicka; Lucie Rárová; Rafal R Sicinski; Aneta M Tomkiel; Jacek W Morzycki

doi:10.3390/molecules25030655

Synthesis of New Cisplatin Derivatives from Bile Acids

Molecules. 2020 Feb 4;25(3):655. doi: 10.3390/molecules25030655.

Authors

Barbara Seroka¹, Zenon Łotowski¹, Agnieszka Hryniewicka¹, Lucie Rárová², Rafal R Sicinski³, Aneta M Tomkiel¹, Jacek W Morzycki¹

Affiliations

¹ Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.
² Laboratory of Growth Regulators, Faculty of Science, Palacký University, and Institute of Experimental Botany of the Czech Academy of Sciences, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.
³ Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

Abstract

A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.

Keywords: bile acids; cholic acid; deoxycholic acid; hyodeoxycholic acid; lithocholic acid; platinum(II) complexes; steroidal diamines.

MeSH terms

Bile Acids and Salts / chemistry*
Cell Proliferation / drug effects
Cell Survival / drug effects
Cisplatin / analogs & derivatives*
Drug Design
HeLa Cells
Human Umbilical Vein Endothelial Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Molecular Structure
Platinum Compounds / chemical synthesis*
Platinum Compounds / chemistry
Platinum Compounds / pharmacology

Substances

Bile Acids and Salts
Platinum Compounds
Cisplatin

Abstract

MeSH terms

Substances

Grants and funding