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Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells.
Ndreshkjana B, Çapci A, Klein V, Chanvorachote P, Muenzner JK, Huebner K, Steinmann S, Erlenbach-Wuensch K, Geppert CI, Agaimy A, Ballout F, El-Baba C, Gali-Muhtasib H, Roehe AV, Hartmann A, Tsogoeva SB, Schneider-Stock R. Ndreshkjana B, et al. Among authors: klein v. Cell Death Dis. 2019 May 16;10(6):379. doi: 10.1038/s41419-019-1611-4. Cell Death Dis. 2019. PMID: 31097715 Free PMC article.
Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB. Çapcı Karagöz A, et al. Among authors: klein v. Bioorg Med Chem. 2018 Jul 23;26(12):3610-3618. doi: 10.1016/j.bmc.2018.05.041. Epub 2018 May 24. Bioorg Med Chem. 2018. PMID: 29887512
Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.
Reiter C, Capcı Karagöz A, Fröhlich T, Klein V, Zeino M, Viertel K, Held J, Mordmüller B, Emirdağ Öztürk S, Anıl H, Efferth T, Tsogoeva SB. Reiter C, et al. Among authors: klein v. Eur J Med Chem. 2014 Mar 21;75:403-12. doi: 10.1016/j.ejmech.2014.01.043. Epub 2014 Jan 31. Eur J Med Chem. 2014. PMID: 24561670