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Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Jelínek M, Balušíková K, Daniel P, Němcová-Fürstová V, Kirubakaran P, Jaček M, Wei L, Wang X, Vondrášek J, Ojima I, Kovář J. Jelínek M, et al. Among authors: nemcova furstova v. Toxicol Appl Pharmacol. 2018 May 15;347:79-91. doi: 10.1016/j.taap.2018.04.002. Epub 2018 Apr 4. Toxicol Appl Pharmacol. 2018. PMID: 29625142 Free PMC article.
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.
Jelínek M, Balušíková K, Kopperová D, Nĕmcová-Fürstová V, Šrámek J, Fidlerová J, Zanardi I, Ojima I, Kovář J. Jelínek M, et al. Among authors: nemcova furstova v. Cancer Cell Int. 2013 May 15;13(1):42. doi: 10.1186/1475-2867-13-42. Cancer Cell Int. 2013. PMID: 23672670 Free PMC article.
Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target.
Brynychova V, Hlavac V, Ehrlichova M, Vaclavikova R, Nemcova-Furstova V, Pecha V, Trnkova M, Mrhalova M, Kodet R, Vrana D, Gatek J, Bendova M, Vernerova Z, Kovar J, Soucek P. Brynychova V, et al. Among authors: nemcova furstova v. Clin Chem Lab Med. 2017 Jan 1;55(1):111-122. doi: 10.1515/cclm-2016-0271. Clin Chem Lab Med. 2017. PMID: 27327132
The role of individual caspases in cell death induction by taxanes in breast cancer cells.
Jelínek M, Balušíková K, Schmiedlová M, Němcová-Fürstová V, Šrámek J, Stančíková J, Zanardi I, Ojima I, Kovář J. Jelínek M, et al. Among authors: nemcova furstova v. Cancer Cell Int. 2015 Feb 4;15(1):8. doi: 10.1186/s12935-015-0155-7. eCollection 2015. Cancer Cell Int. 2015. PMID: 25685064 Free PMC article.
17 results