Silicic magmatic systems are the most dangerous volcanoes on Earth, capable of large and catastrophic eruptions, yet their low eruptive frequency makes it challenging to interpret their short-term unrest. Here we present a decade-plus analysis that integrates, for the first time, time series of satellite interferometric synthetic aperture radar (InSAR) surface deformation and satellite thermal infrared edifice-scale surface warming at a large silicic system: Domuyo volcano, in Argentina. We find that deformation and warming are highly correlated, and depending on the sign and lag between the time series, either shallow sealing or magma influx could drive Domuyo's ongoing inflation (~ 0.15 m/year; from an InSAR-derived tabular source, ~ 11 × 8 × 1 km; ~ 6.5 km depth; ~ 0.037 km3/year volume-change rate) and warming (0.3-0.4 °C/year). This study shows the potential that combined satellite surface deformation and edifice-scale surface warming time series have on assessing the physical mechanisms of silicic volcanic systems and for constraining deterministic models.