Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh

Molecules. 2012 Dec 21;18(1):128-39. doi: 10.3390/molecules18010128.

Abstract

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50)value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Aporphines / isolation & purification
  • Aporphines / pharmacology
  • Benzamides / isolation & purification
  • Benzamides / pharmacology
  • Cinnamates / isolation & purification
  • Cinnamates / pharmacology
  • Goniothalamus / chemistry*
  • HT29 Cells
  • Heterocyclic Compounds / isolation & purification
  • Heterocyclic Compounds / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plant Bark / chemistry*
  • Plant Extracts / pharmacology*
  • Plant Stems / chemistry*
  • Pyrans / isolation & purification
  • Pyrans / pharmacology
  • Pyrones / isolation & purification
  • Pyrones / pharmacology
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Antioxidants
  • Aporphines
  • Benzamides
  • Cinnamates
  • Heterocyclic Compounds
  • Lactones
  • Plant Extracts
  • Pyrans
  • Pyrones
  • Sesquiterpenes
  • pterodondiol
  • 9-deoxygoniopypyrone
  • cinnamic acid
  • goniothalamin
  • benzamide
  • liriodenine