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Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.
Vanova T, Sedmik J, Raska J, Amruz Cerna K, Taus P, Pospisilova V, Nezvedova M, Fedorova V, Kadakova S, Klimova H, Capandova M, Orviska P, Fojtik P, Bartova S, Plevova K, Spacil Z, Hribkova H, Bohaciakova D. Vanova T, et al. Among authors: fedorova v. Cell Rep. 2023 Nov 28;42(11):113310. doi: 10.1016/j.celrep.2023.113310. Epub 2023 Oct 20. Cell Rep. 2023. PMID: 37864790 Free article.
Differentiation of neural rosettes from human pluripotent stem cells in vitro is sequentially regulated on a molecular level and accomplished by the mechanism reminiscent of secondary neurulation.
Fedorova V, Vanova T, Elrefae L, Pospisil J, Petrasova M, Kolajova V, Hudacova Z, Baniariova J, Barak M, Peskova L, Barta T, Kaucka M, Killinger M, Vecera J, Bernatik O, Cajanek L, Hribkova H, Bohaciakova D. Fedorova V, et al. Stem Cell Res. 2019 Oct;40:101563. doi: 10.1016/j.scr.2019.101563. Epub 2019 Aug 29. Stem Cell Res. 2019. PMID: 31494448 Free article.