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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644.
Sci Rep. 2016.
PMID: 27995962
Free PMC article.
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues.
Phillips JJ, Buchanan A, Andrews J, Chodorge M, Sridharan S, Mitchell L, Burmeister N, Kippen AD, Vaughan TJ, Higazi DR, Lowe D.
Phillips JJ, et al. Among authors: vaughan tj.
Anal Chem. 2017 Feb 21;89(4):2361-2368. doi: 10.1021/acs.analchem.6b04158. Epub 2017 Feb 3.
Anal Chem. 2017.
PMID: 28194941
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