Quantitative prediction of human pharmacokinetics for mAbs exhibiting target-mediated disposition.
Singh AP, Krzyzanski W, Martin SW, Weber G, Betts A, Ahmad A, Abraham A, Zutshi A, Lin J, Singh P.
Singh AP, et al.
AAPS J. 2015 Mar;17(2):389-99. doi: 10.1208/s12248-014-9690-8. Epub 2014 Dec 3.
AAPS J. 2015.
PMID: 25445845
Free PMC article.
AAFE of less than two-fold was observed between monkey and human for baseline target levels (R 0), body-weight (BW) normalized central elimination rate (K el/BW(-0.25)) and central volume (V c/BW(1.0)). AAFE of less than three-fold was estimated for the binding affinity co …
AAFE of less than two-fold was observed between monkey and human for baseline target levels (R 0), body-weight (BW) normalized central elimi …