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Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce ehlers-danlos syndrome type I.
Michalickova K, Susic M, Willing MC, Wenstrup RJ, Cole WG. Michalickova K, et al. Hum Mol Genet. 1998 Feb;7(2):249-55. doi: 10.1093/hmg/7.2.249. Hum Mol Genet. 1998. PMID: 9425231
We have identified mutations of the COL5A2 gene, which encodes the alpha2(V) chain of type V collagen, in two unrelated patients with the severe type I form of EDS. ...Bone cells from the first proband also produced about equal amounts of the normal and mutant alpha …
We have identified mutations of the COL5A2 gene, which encodes the alpha2(V) chain of type V collagen, in two unrelated patien …
COL5A1 haploinsufficiency is a common molecular mechanism underlying the classical form of EDS.
Wenstrup RJ, Florer JB, Willing MC, Giunta C, Steinmann B, Young F, Susic M, Cole WG. Wenstrup RJ, et al. Am J Hum Genet. 2000 Jun;66(6):1766-76. doi: 10.1086/302930. Epub 2000 Apr 24. Am J Hum Genet. 2000. PMID: 10777716 Free PMC article.
We have identified haploinsufficiency of the COL5A1 gene that encodes the proalpha1(V) chain of type V collagen in the classical form of the Ehlers-Danlos syndrome (EDS), a heritable connective-tissue disorder that severely alters the collagen-fibrillar structure of …
We have identified haploinsufficiency of the COL5A1 gene that encodes the proalpha1(V) chain of type V collagen in the classic …
Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial.
Foeldvari I, Constantin T, Vojinović J, Horneff G, Chasnyk V, Dehoorne J, Panaviene V, Sušić G, Stanevicha V, Kobusinska K, Zuber Z, Dobrzyniecka B, Nikishina I, Bader-Meunier B, Breda L, Doležalová P, Job-Deslandre C, Rumba-Rozenfelde I, Wulffraat N, Pedersen RD, Bukowski JF, Vlahos B, Martini A, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO). Foeldvari I, et al. Arthritis Res Ther. 2019 May 23;21(1):125. doi: 10.1186/s13075-019-1916-9. Arthritis Res Ther. 2019. PMID: 31122296 Free PMC article. Clinical Trial.
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Zivanovic D, Stanojlovic O, Susic V, Stojanovic J. Zivanovic D, et al. Acta Neurol Belg. 2004 Mar;104(1):20-6. Acta Neurol Belg. 2004. PMID: 15143958
The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i.c.v.) administration of imipenem/cilastatin (Imi/Cil). Under intraperitoneal (i.p.) sodium pentobarbital anesthesi …
The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracer …
Clinical characteristics and genetic analyses of 187 patients with undefined autoinflammatory diseases.
Ter Haar NM, Eijkelboom C, Cantarini L, Papa R, Brogan PA, Kone-Paut I, Modesto C, Hofer M, Iagaru N, Fingerhutová S, Insalaco A, Licciardi F, Uziel Y, Jelusic M, Nikishina I, Nielsen S, Papadopoulou-Alataki E, Olivieri AN, Cimaz R, Susic G, Stanevica V, van Gijn M, Vitale A, Ruperto N, Frenkel J, Gattorno M; Eurofever registry and the Pediatric Rheumatology International Trial Organization (PRINTO). Ter Haar NM, et al. Ann Rheum Dis. 2019 Oct;78(10):1405-1411. doi: 10.1136/annrheumdis-2018-214472. Epub 2019 Jul 5. Ann Rheum Dis. 2019. PMID: 31278138
Dose-dependent anticonvulsive effect of ethanol on lindane-induced seizures in rats.
Mladenović D, Hrncić D, Radosavljević T, Vucević D, Djurić D, Rasić-Marković A, Macut D, Susić V, Sćepanović L, Stanojlović O. Mladenović D, et al. Can J Physiol Pharmacol. 2008 Apr;86(4):148-52. doi: 10.1139/Y08-009. Can J Physiol Pharmacol. 2008. PMID: 18418422
Male Wistar rats were injected i.p. with one of the following 5 treatments: (i) saline, (ii) dimethylsulfoxide, (iii) lindane (8 mg/kg) (L), (iv) ethanol in doses of 0.5 g/kg (E(0.5)), 1 g/kg (E(1)), and 2 g/kg (E(2)), and (v) groups that received ethanol 30 min before lin …
Male Wistar rats were injected i.p. with one of the following 5 treatments: (i) saline, (ii) dimethylsulfoxide, (iii) lindane (8 mg/kg) (L), …
Cardiac structural and functional responses to salt loading in SHR.
Ahn J, Varagic J, Slama M, Susic D, Frohlich ED. Ahn J, et al. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H767-72. doi: 10.1152/ajpheart.00047.2004. Epub 2004 Apr 1. Am J Physiol Heart Circ Physiol. 2004. PMID: 15059772 Free article.
In most SHR, salt excess increased arterial pressure, LV mass, and hydroxyproline concentration and impaired LV relaxation manifested by prolonged isovolumic relaxation time, decreased early and atrial filling velocity ratio (V(E)/V(A)), and slower propagation veloc …
In most SHR, salt excess increased arterial pressure, LV mass, and hydroxyproline concentration and impaired LV relaxation manifested by pro …
Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats.
Susic D, Varagic J, Ahn J, Frohlich ED. Susic D, et al. Am J Hypertens. 2004 Apr;17(4):328-33. doi: 10.1016/j.amjhyper.2003.12.015. Am J Hypertens. 2004. PMID: 15062886

ALT-711 also reduced left ventricular hydroxyproline concentration (5.8 +/- 0.2 v 5.1 +/- 0.3 mg/g in controls, P < .05); however, it did not affect systemic or regional hemodynamics. ...Systolic pressure remained unchanged in placebo-treated rats. In addition, left ven

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ALT-711 also reduced left ventricular hydroxyproline concentration (5.8 +/- 0.2 v 5.1 +/- 0.3 mg/g in controls, P < .05); however,

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The effect of acute and chronic hematocrit changes on cardiovascular hemodynamics in spontaneously hypertensive rats.
Susic D, Mandal AK, Jovovic D, Veljkovic V, Panajotovic V, Bell RD, Kentera D. Susic D, et al. Am J Hypertens. 1992 Oct;5(10):713-8. doi: 10.1093/ajh/5.10.713. Am J Hypertens. 1992. PMID: 1418834

Thus, chronic hematocrit decrease induced by H or P resulted in a significant fall in blood pressure compared to control (201 +/- 3 v 175 +/- 4, 167 +/- 4 mm Hg, respectively; P < .05). Conversely, a chronic hematocrit increase resulted in a significant rise in blood pr

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Thus, chronic hematocrit decrease induced by H or P resulted in a significant fall in blood pressure compared to control (201 +/- 3 v …
Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.
Zivanovic D, Lovic OS, Susic V. Zivanovic D, et al. Indian J Med Res. 2004 Feb;119(2):79-85. Indian J Med Res. 2004. PMID: 15055488
Animals were divided into five groups: (i) saline (icv)+Imi/Cil (ii) APV (0.2 micromol)+Imi/Cil, (iii) APV (0.4 micromol)+Imi/Cil, (iv) remacemide (100 mg/kg, ip)+Imi/Cil, and (v) HA-966 (200 microg, icv)+Imi/Cil. The drugs were administered 30 min before icv injection of …
Animals were divided into five groups: (i) saline (icv)+Imi/Cil (ii) APV (0.2 micromol)+Imi/Cil, (iii) APV (0.4 micromol)+Imi/Cil, (iv) rema …
14 results