Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy.
Madhusudhan T, Ghosh S, Wang H, Dong W, Gupta D, Elwakiel A, Stoyanov S, Al-Dabet MM, Krishnan S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi I, Rana R, Zeng-Brouwers J, Moeller MJ, Schaefer L, Esmon CT, Kohli S, Reiser J, Rezaie AR, Ruf W, Isermann B.
Madhusudhan T, et al.
J Am Soc Nephrol. 2020 Aug;31(8):1762-1780. doi: 10.1681/ASN.2019111163. Epub 2020 Jul 24.
J Am Soc Nephrol. 2020.
PMID: 32709711
Free PMC article.
The interaction of aPC with integrin-alpha(v)beta(3) induces transient binding of integrin-beta(3) with G (alpha13) and controls PAR-dependent RhoA signaling in podocytes. ...These results identify integrin-alpha(v)beta(3) as an essential coreceptor for aPC that is …
The interaction of aPC with integrin-alpha(v)beta(3) induces transient binding of integrin-beta(3) with G (alpha13) and controls PAR- …