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URI is required to maintain intestinal architecture during ionizing radiation.
Chaves-Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N. Chaves-Pérez A, et al. Science. 2019 May 31;364(6443):eaaq1165. doi: 10.1126/science.aaq1165. Science. 2019. PMID: 31147493
We show that high-dose irradiation increases unconventional prefoldin RPB5 interactor (URI) levels in mouse intestinal crypt, but organ regeneration correlates with URI reductions. URI overexpression in intestine protects mice from radiation-induced GIS, wher …
We show that high-dose irradiation increases unconventional prefoldin RPB5 interactor (URI) levels in mouse intestinal crypt, but org …
Coming of Age of Immunotherapy of Urothelial Cancer.
Grande E, Molina-Cerrillo J, Necchi A. Grande E, et al. Target Oncol. 2021 May;16(3):283-294. doi: 10.1007/s11523-021-00804-7. Epub 2021 Mar 12. Target Oncol. 2021. PMID: 33710533 Review.
Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Bernard H, Teijeiro A, Chaves-Pérez A, Perna C, Satish B, Novials A, Wang JP, Djouder N. Bernard H, et al. Cell Rep Med. 2020 Oct 20;1(7):100125. doi: 10.1016/j.xcrm.2020.100125. eCollection 2020 Oct 20. Cell Rep Med. 2020. PMID: 33205075 Free PMC article.
Consequently, demethylating agent procainamide-mediated DNMT1 inhibition reinstates PDX1 expression and protects against diabetes in pancreatic URI-depleted mice . Finally, the beta cells of human diabetes patients show correlations between viral protein 1 and URI, …
Consequently, demethylating agent procainamide-mediated DNMT1 inhibition reinstates PDX1 expression and protects against diabetes in pancrea …
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation.
Chaves-Pérez A, Santos-de-Frutos K, de la Rosa S, Herranz-Montoya I, Perna C, Djouder N. Chaves-Pérez A, et al. J Exp Med. 2022 Nov 7;219(11):e20212405. doi: 10.1084/jem.20212405. Epub 2022 Sep 13. J Exp Med. 2022. PMID: 36098959 Free PMC article.
Here, we demonstrate that transit-amplifying (TA) cells, marked by unconventional prefoldin RPB5 interactor (URI), control R-spondin production to guide ISC proliferation. Genetic intestinal URI ablation in mice injures TA cells, reducing their survival capacity, le …
Here, we demonstrate that transit-amplifying (TA) cells, marked by unconventional prefoldin RPB5 interactor (URI), control R-spondin …
Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.
Gomes AL, Teijeiro A, Burén S, Tummala KS, Yilmaz M, Waisman A, Theurillat JP, Perna C, Djouder N. Gomes AL, et al. Cancer Cell. 2016 Jul 11;30(1):161-175. doi: 10.1016/j.ccell.2016.05.020. Cancer Cell. 2016. PMID: 27411590 Free article.
We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymph …
We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic st …
11 results