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Page 1
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: julku uh. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
PET Imaging in Preclinical Anti-Aβ Drug Development.
Syvänen S, Meier SR, Roshanbin S, Xiong M, Faresjö R, Gustavsson T, Bonvicini G, Schlein E, Aguilar X, Julku U, Eriksson J, Sehlin D. Syvänen S, et al. Among authors: julku u. Pharm Res. 2022 Jul;39(7):1481-1496. doi: 10.1007/s11095-022-03277-z. Epub 2022 May 2. Pharm Res. 2022. PMID: 35501533 Free PMC article. Review.
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.
Kilpeläinen TP, Pätsi HT, Svarcbahs R, Julku UH, Eteläinen TS, Cui H, Auno S, Sipari N, Norrbacka S, Leino TO, Jäntti M, Myöhänen TT, Wallén EAA. Kilpeläinen TP, et al. Among authors: julku uh. J Med Chem. 2023 Jun 8;66(11):7475-7496. doi: 10.1021/acs.jmedchem.3c00235. Epub 2023 May 29. J Med Chem. 2023. PMID: 37248563 Free PMC article.
16 results