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Year Number of Results
2002 1
2004 1
2006 2
2008 1
2012 1
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2017 1
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2019 2
2020 2
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2023 5
2024 3

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Page 1
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Otake K, Ubukata M, Nagahashi N, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: adachi t. ACS Med Chem Lett. 2023 Apr 7;14(5):658-665. doi: 10.1021/acsmedchemlett.3c00067. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197451
Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide.
Ohba Y, Adachi K, Furukawa T, Nishimaru T, Sakurai K, Masuo R, Inami T, Orita T, Akai S, Adachi T, Usui K, Hamada Y, Mori M, Kurimoto T, Wakashima T, Akiyama Y, Miyazaki S, Noji S. Ohba Y, et al. Among authors: adachi t. ACS Med Chem Lett. 2023 Nov 10;14(12):1833-1838. doi: 10.1021/acsmedchemlett.3c00433. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116417
Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents.
Miwa S, Yokota M, Ueyama Y, Maeda K, Ogoshi Y, Seki N, Ogawa N, Nishihata J, Nomura A, Adachi T, Kitao Y, Nozawa K, Ishikawa T, Ukaji Y, Shiozaki M. Miwa S, et al. Among authors: adachi t. ACS Med Chem Lett. 2021 Apr 21;12(5):745-751. doi: 10.1021/acsmedchemlett.0c00679. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055221 Free PMC article.
Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.
Kotoku M, Maeba T, Fujioka S, Yokota M, Seki N, Ito K, Suwa Y, Ikenogami T, Hirata K, Hase Y, Katsuda Y, Miyagawa N, Arita K, Asahina K, Noguchi M, Nomura A, Doi S, Adachi T, Crowe P, Tao H, Thacher S, Hashimoto H, Suzuki T, Shiozaki M. Kotoku M, et al. Among authors: adachi t. J Med Chem. 2019 Mar 14;62(5):2837-2842. doi: 10.1021/acs.jmedchem.8b01567. Epub 2019 Mar 1. J Med Chem. 2019. PMID: 30776227
Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: adachi t. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Otake K, Hara Y, Ubukata M, Inoue M, Nagahashi N, Motoda D, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: adachi t. J Med Chem. 2024 Mar 14;67(5):3741-3763. doi: 10.1021/acs.jmedchem.3c02171. Epub 2024 Feb 26. J Med Chem. 2024. PMID: 38408347
25 results