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Page 1
Nonhuman targets in allergic lung conditions.
Robinson C, Zhang J, Newton GK, Perrior TR. Robinson C, et al. Among authors: perrior tr. Future Med Chem. 2013 Feb;5(2):147-61. doi: 10.4155/fmc.12.204. Future Med Chem. 2013. PMID: 23360140 Review.
Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Zhang J, Chen J, Richardson JP, Francis-Newton NJ, Lai PF, Jenkins K, Major MR, Key RE, Stewart ME, Firth-Clark S, Lloyd SM, Newton GK, Perrior TR, Garrod DR, Robinson C. Zhang J, et al. Among authors: perrior tr. ACS Pharmacol Transl Sci. 2022 Aug 12;5(9):735-751. doi: 10.1021/acsptsci.2c00022. eCollection 2022 Sep 9. ACS Pharmacol Transl Sci. 2022. PMID: 36110379 Free PMC article.
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Webster SP, et al. Among authors: perrior tr. Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. Br J Pharmacol. 2017. PMID: 28012176 Free PMC article. Clinical Trial.
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C. Newton GK, et al. Among authors: perrior tr. J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17. J Med Chem. 2014. PMID: 25365789 Free PMC article.