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Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells.
Kawamura T, Liu D, Towle MJ, Kageyama R, Tsukahara N, Wakabayashi T, Littlefield BA. Kawamura T, et al. Among authors: wakabayashi t. J Antibiot (Tokyo). 2003 Aug;56(8):709-15. doi: 10.7164/antibiotics.56.709. J Antibiot (Tokyo). 2003. PMID: 14563161 Free article.
Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage.
Yamamoto Y, Matsui J, Matsushima T, Obaishi H, Miyazaki K, Nakamura K, Tohyama O, Semba T, Yamaguchi A, Hoshi SS, Mimura F, Haneda T, Fukuda Y, Kamata JI, Takahashi K, Matsukura M, Wakabayashi T, Asada M, Nomoto KI, Watanabe T, Dezso Z, Yoshimatsu K, Funahashi Y, Tsuruoka A. Yamamoto Y, et al. Among authors: wakabayashi t. Vasc Cell. 2014 Sep 6;6:18. doi: 10.1186/2045-824X-6-18. eCollection 2014. Vasc Cell. 2014. PMID: 25197551 Free PMC article.