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Showing results for tor medale
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Rainbow trout genetically selected for greater muscle fat content display increased activation of liver TOR signaling and lipogenic gene expression.
Skiba-Cassy S, Lansard M, Panserat S, Médale F. Skiba-Cassy S, et al. Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1421-9. doi: 10.1152/ajpregu.00312.2009. Epub 2009 Aug 26. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19710390 Free article.
Whereas glycemia returned to basal level 24 h after refeeding in FL trout, it remained elevated in the LL trout. Target of rapamycin (TOR) protein was more abundant in the livers of FL trout than in LL trout, and refeeding activation of the hepatic TOR signaling pat …
Whereas glycemia returned to basal level 24 h after refeeding in FL trout, it remained elevated in the LL trout. Target of rapamycin (TOR
Hepatic protein kinase B (Akt)-target of rapamycin (TOR)-signalling pathways and intermediary metabolism in rainbow trout (Oncorhynchus mykiss) are not significantly affected by feeding plant-based diets.
Lansard M, Panserat S, Seiliez I, Polakof S, Plagnes-Juan E, Geurden I, Médale F, Kaushik S, Corraze G, Skiba-Cassy S. Lansard M, et al. Br J Nutr. 2009 Dec;102(11):1564-73. doi: 10.1017/S000711450999095X. Epub 2009 Aug 10. Br J Nutr. 2009. PMID: 19664314 Clinical Trial.
The insulin-nutrient-signalling pathway (protein kinase B (Akt), target of rapamycin (TOR), S6 protein kinase 1 (S6K1) and S6) was characterised in trout liver and found to be activated by refeeding. However, changes in diet compositions did not differentially affect the A …
The insulin-nutrient-signalling pathway (protein kinase B (Akt), target of rapamycin (TOR), S6 protein kinase 1 (S6K1) and S6) was ch …
Insulin regulates lipid and glucose metabolism similarly in two lines of rainbow trout divergently selected for muscle fat content.
Jin J, Panserat S, Kamalam BS, Aguirre P, Véron V, Médale F. Jin J, et al. Gen Comp Endocrinol. 2014 Aug 1;204:49-59. doi: 10.1016/j.ygcen.2014.04.027. Epub 2014 May 14. Gen Comp Endocrinol. 2014. PMID: 24830905
In order to test this hypothesis, bovine insulin was injected into rainbow trout of the two lines fasted for 48 h. As expected, insulin induced hypoglycemia and activated Akt-TOR signaling both in the liver and muscle of the two lines. We demonstrate that this was coupled …
In order to test this hypothesis, bovine insulin was injected into rainbow trout of the two lines fasted for 48 h. As expected, insulin indu …
Regulation of metabolism by dietary carbohydrates in two lines of rainbow trout divergently selected for muscle fat content.
Kamalam BS, Medale F, Kaushik S, Polakof S, Skiba-Cassy S, Panserat S. Kamalam BS, et al. J Exp Biol. 2012 Aug 1;215(Pt 15):2567-78. doi: 10.1242/jeb.070581. J Exp Biol. 2012. PMID: 22786633
In both lines, intake of carbohydrates was associated with a moderate post-prandial hyperglycaemia, a protein sparing effect, an enhancement of nutrient (TOR-S6) signalling cascade and a decrease of energy-sensing enzyme (AMPK). ...
In both lines, intake of carbohydrates was associated with a moderate post-prandial hyperglycaemia, a protein sparing effect, an enhancement …
Comparison of glucose and lipid metabolic gene expressions between fat and lean lines of rainbow trout after a glucose load.
Jin J, Médale F, Kamalam BS, Aguirre P, Véron V, Panserat S. Jin J, et al. PLoS One. 2014 Aug 20;9(8):e105548. doi: 10.1371/journal.pone.0105548. eCollection 2014. PLoS One. 2014. PMID: 25141351 Free PMC article.
Hyperglycemia was observed after glucose treatment in both lines without affecting the phosphorylation of AMPK (cellular energy sensor) and Akt-TOR (insulin signaling) components. Liver glucokinase and glucose-6-phosphate dehydrogenase expression levels were increased by g …
Hyperglycemia was observed after glucose treatment in both lines without affecting the phosphorylation of AMPK (cellular energy sensor) and …