Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity.
Kang C, Yun D, Yoon H, Hong M, Hwang J, Shin HM, Park S, Cheon S, Han D, Moon KC, Kim HY, Choi EY, Lee EY, Kim MH, Jeong CW, Kwak C, Kim DK, Oh KH, Joo KW, Lee DS, Kim YS, Han SS.
Kang C, et al.
Kidney Int. 2024 Feb 5:S0085-2538(24)00067-X. doi: 10.1016/j.kint.2024.01.011. Online ahead of print.
Kidney Int. 2024.
PMID: 38320721
The proliferation capacity of both CD4(+) and CD8(+) T cells, along with interleukin-17 production of gammadelta T cells, was higher in the kidneys of TIN-induced Eprs1(+/+) mice than in the kidneys of TIN-induced Eprs1(+/-) mice. ...Thus, EPRS1 may emerge as a ther …
The proliferation capacity of both CD4(+) and CD8(+) T cells, along with interleukin-17 production of gammadelta T cells, was higher in the …