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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, … See abstract for full author list ➔ Sims R, et al. Nat Genet. 2017 Sep;49(9):1373-1384. doi: 10.1038/ng.3916. Epub 2017 Jul 17. Nat Genet. 2017. PMID: 28714976 Free PMC article.

In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the mo

In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 10(-4)) i

Insulin therapy associated relative hypoglycemia during critical illness.
Kwan TN, Marhoon N, Young M, Holmes N, Bellomo R. Kwan TN, et al. J Crit Care. 2022 Aug;70:154018. doi: 10.1016/j.jcrc.2022.154018. Epub 2022 Apr 5. J Crit Care. 2022. PMID: 35395469

RESULTS: ITARH occurred in 184 (42%) of insulin-treated patients. ITARH was associated with a higher HbA1c (8.6% vs 6.6%, p < 0.001), a higher glycemic variability index (121 vs 75.1 mmol(2)/L(2)/h/week, p < 0.001) and more absolute hypoglycemia (18.5% vs 3.94

RESULTS: ITARH occurred in 184 (42%) of insulin-treated patients. ITARH was associated with a higher HbA1c (8.6% vs 6.6%, p < 0.00

Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor.
Avgoustou P, Jailani ABA, Zirimwabagabo JO, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay PJ, Wang N, Shaw AP, Bigos KJA, Holmes JL, Warrington JI, Skerry TM, Harrity JPA, Richards GO. Avgoustou P, et al. ACS Pharmacol Transl Sci. 2020 Jun 25;3(4):706-719. doi: 10.1021/acsptsci.0c00032. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832872 Free PMC article.
Antimicrobial stewardship: are we failing in cross-specialty clinical engagement?
Rawson TM, Moore LS, Gilchrist MJ, Holmes AH. Rawson TM, et al. J Antimicrob Chemother. 2016 Feb;71(2):554-9. doi: 10.1093/jac/dkv337. Epub 2015 Oct 23. J Antimicrob Chemother. 2016. PMID: 26498747 Free PMC article.

The UK had a significantly greater proportion of AMS-AMR-related abstracts compared with international conferences [2.8% (n = 221/7843) compared with 1.8% (n = 942/51,839); P < 0.001]. Infection conferences contained the greatest proportion of AMS-AMR abstracts, represe

The UK had a significantly greater proportion of AMS-AMR-related abstracts compared with international conferences [2.8% (n = 221/7843) comp …
Initial safety analysis of a randomized phase II trial of nelipepimut-S + GM-CSF and trastuzumab compared to trastuzumab alone to prevent recurrence in breast cancer patients with HER2 low-expressing tumors.
Clifton GT, Peace KM, Holmes JP, Vreeland TJ, Hale DF, Herbert GS, Litton JK, Murthy RK, Lukas J, Peoples GE, Mittendorf Elizabeth A. Clifton GT, et al. Clin Immunol. 2019 Apr;201:48-54. doi: 10.1016/j.clim.2019.02.011. Epub 2019 Feb 25. Clin Immunol. 2019. PMID: 30817999 Clinical Trial.
Rapid cloud removal of dimethyl sulfide oxidation products limits SO2 and cloud condensation nuclei production in the marine atmosphere.
Novak GA, Fite CH, Holmes CD, Veres PR, Neuman JA, Faloona I, Thornton JA, Wolfe GM, Vermeuel MP, Jernigan CM, Peischl J, Ryerson TB, Thompson CR, Bourgeois I, Warneke C, Gkatzelis GI, Coggon MM, Sekimoto K, Bui TP, Dean-Day J, Diskin GS, DiGangi JP, Nowak JB, Moore RH, Wiggins EB, Winstead EL, Robinson C, Thornhill KL, Sanchez KJ, Hall SR, Ullmann K, Dollner M, Weinzierl B, Blake DR, Bertram TH. Novak GA, et al. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2110472118. doi: 10.1073/pnas.2110472118. Proc Natl Acad Sci U S A. 2021. PMID: 34635596 Free PMC article.
δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients.
Qureshi AA, Khan DA, Mushtaq S, Ye SQ, Xiong M, Qureshi N. Qureshi AA, et al. Lipids Health Dis. 2018 Jul 21;17(1):167. doi: 10.1186/s12944-018-0804-7. Lipids Health Dis. 2018. PMID: 30031388 Free PMC article.
IPA of "causal network" indicated gene regulators (676), in which 76 down-regulated (26 s proteasomes, interleukin cytokines, and PPAR-ligand-PPA-Retinoic acid-RXRalpha, PPARgamma-ligand-PPARgamma-Retinoic acid-RARalpha, IL-21, IL-23) with significant P-values. The IPA of …
IPA of "causal network" indicated gene regulators (676), in which 76 down-regulated (26 s proteasomes, interleukin cytokines, and PPAR-ligan …