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Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells.
Lee KM, Kim JI, Stott R, Soohoo J, O'Connor MR, Yeh H, Zhao G, Eliades P, Fox C, Cheng N, Deng S, Markmann JF. Lee KM, et al. Am J Transplant. 2012 Aug;12(8):2072-8. doi: 10.1111/j.1600-6143.2012.04055.x. Epub 2012 Apr 11. Am J Transplant. 2012. PMID: 22494812 Free PMC article.
We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all recipients in a mouse islet allograft model. . …
We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in co …
TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.
Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P. Vergani A, et al. Cell Transplant. 2015;24(8):1599-1614. doi: 10.3727/096368914X678571. Epub 2014 Mar 7. Cell Transplant. 2015. PMID: 24612609 Free PMC article.
Detection of alloreactive T cells from cryopreserved human peripheral blood mononuclear cells.
Tanimine N, Burrell BE, Deng K, Rickert C, Lee KM, Feeney N, Pardo J, LeGuern C, Markmann JF. Tanimine N, et al. J Immunol Methods. 2021 Apr;491:112987. doi: 10.1016/j.jim.2021.112987. Epub 2021 Feb 6. J Immunol Methods. 2021. PMID: 33556344
We defined subsets of CD4+ and CD8+ T cells co-expressing CD69 and either CD154 or CD137 following allostimulation as alloreactive, and further phenotyped these cells with a variety of surface markers such as PD-1, LAG-3, and TIM-3. This assay may allow for the monitoring …
We defined subsets of CD4+ and CD8+ T cells co-expressing CD69 and either CD154 or CD137 following allostimulation as alloreactive, and furt …
Regulatory B Cell-Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent.
Schuetz C, Lee KM, Scott R, Kojima L, Washburn L, Liu L, Liu WH, Tector H, Lei J, Yeh H, Kim JI, Markmann JF. Schuetz C, et al. Am J Transplant. 2017 Jun;17(6):1656-1662. doi: 10.1111/ajt.14265. Epub 2017 Apr 11. Am J Transplant. 2017. PMID: 28296255 Free PMC article.
Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models by using antibodies directed at CD45RB and Tim-1. We have shown that this form of tolerance depends on regulatory B cells (Bregs). ...
Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models by using antibodies directed at CD45RB …