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C5-Iminosugar modification of casein kinase 1δ lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity.
Arch Pharm (Weinheim). 2022 May;355(5):e2100497. doi: 10.1002/ardp.202100497. Epub 2022 Feb 17.
Arch Pharm (Weinheim). 2022.
PMID: 35174898
Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.
Luxenburger A, Schmidt D, Ianes C, Pichlo C, Krüger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C.
Luxenburger A, et al. Among authors: von drathen t.
Molecules. 2019 Mar 1;24(5):873. doi: 10.3390/molecules24050873.
Molecules. 2019.
PMID: 30832206
Free PMC article.
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Visible-Light Cascade Photooxygenation of Tetrahydrocarbazoles and Cyclohepta[b]indoles: Access to C,N-Diacyliminium Ions.
Frahm M, von Drathen T, Gronbach LM, Voss A, Lorenz F, Bresien J, Villinger A, Hoffmann F, Brasholz M.
Frahm M, et al. Among authors: von drathen t.
Angew Chem Int Ed Engl. 2020 Jul 20;59(30):12450-12454. doi: 10.1002/anie.202007549. Epub 2020 Jun 23.
Angew Chem Int Ed Engl. 2020.
PMID: 32501642
Free PMC article.
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Visible-Light Catalytic Photooxygenation of Monoterpene Indole Alkaloids: Access to Spirooxindole-1,3-oxazines.
von Drathen T, Hoffmann F, Brasholz M.
von Drathen T, et al.
Chemistry. 2018 Jul 17;24(40):10253-10259. doi: 10.1002/chem.201801882. Epub 2018 Jun 22.
Chemistry. 2018.
PMID: 29750377
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Photoinduced Conversion of Antimelanoma Agent Dabrafenib to a Novel Fluorescent BRAFV600E Inhibitor.
Pinchuk B, von Drathen T, Opel V, Peifer C.
Pinchuk B, et al. Among authors: von drathen t.
ACS Med Chem Lett. 2016 Sep 20;7(10):962-966. doi: 10.1021/acsmedchemlett.6b00340. eCollection 2016 Oct 13.
ACS Med Chem Lett. 2016.
PMID: 27774137
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