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A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.
Coutadeur S, Benyamine H, Delalonde L, de Oliveira C, Leblond B, Foucourt A, Besson T, Casagrande AS, Taverne T, Girard A, Pando MP, Désiré L. Coutadeur S, et al. Among authors: taverne t. J Neurochem. 2015 May;133(3):440-51. doi: 10.1111/jnc.13018. Epub 2015 Jan 26. J Neurochem. 2015. PMID: 25556849 Free article.
RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.
Désiré L, Bourdin J, Loiseau N, Peillon H, Picard V, De Oliveira C, Bachelot F, Leblond B, Taverne T, Beausoleil E, Lacombe S, Drouin D, Schweighoffer F. Désiré L, et al. Among authors: taverne t. J Biol Chem. 2005 Nov 11;280(45):37516-25. doi: 10.1074/jbc.M507913200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16150730 Free article.
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.
Beausoleil E, Chauvignac C, Taverne T, Lacombe S, Pognante L, Leblond B, Pallares D, Oliveira CD, Bachelot F, Carton R, Peillon H, Coutadeur S, Picard V, Lambeng N, Désiré L, Schweighoffer F. Beausoleil E, et al. Among authors: taverne t. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5594-8. doi: 10.1016/j.bmcl.2009.08.037. Epub 2009 Aug 13. Bioorg Med Chem Lett. 2009. PMID: 19716293
Vascular disrupting activity and the mechanism of action of EHT 6706, a novel anticancer tubulin polymerization inhibitor.
Belzacq-Casagrande AS, Bachelot F, De Oliveira C, Coutadeur S, Maurier-Mahé F, Throo E, Chauvignac C, Pognante L, Petibon A, Taverne T, Beausoleil E, Leblond B, Pando MP, Désiré L. Belzacq-Casagrande AS, et al. Among authors: taverne t. Invest New Drugs. 2013 Apr;31(2):304-19. doi: 10.1007/s10637-012-9858-y. Epub 2012 Aug 10. Invest New Drugs. 2013. PMID: 22878926