Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease.
Lindner S, Miltiadous O, Ramos RJF, Paredes J, Kousa AI, Dai A, Fei T, Lauder E, Frame J, Waters NR, Sadeghi K, Armijo GK, Ghale R, Victor K, Gipson B, Monette S, Russo MV, Nguyen CL, Slingerland J, Taur Y, Markey KA, Andrlova H, Giralt S, Perales MA, Reddy P, Peled JU, Smith M, Cross JR, Burgos da Silva M, Campbell C, van den Brink MRM.
Lindner S, et al. Among authors: fei t.
Nat Microbiol. 2024 Mar;9(3):614-630. doi: 10.1038/s41564-024-01617-w. Epub 2024 Mar 1.
Nat Microbiol. 2024.
PMID: 38429422
Several microbe-derived bile acids attenuated farnesoid X receptor (FXR) activation, suggesting that loss of these metabolites during inflammation may increase FXR activity and exacerbate the course of disease. Indeed, mortality increased with pharmacological activation of …
Several microbe-derived bile acids attenuated farnesoid X receptor (FXR) activation, suggesting that loss of these metabolites during inflam …