[Bone marrow aplasia associated to the use of ticlopidine]

Rev Med Chil. 2002 Jul;130(7):798-802. doi: 10.4067/S0034-98872002000700013.
[Article in Spanish]

Abstract

We report a 58 years old male that developed a bone marrow aplasia associated to the use of ticlopidine, prescribed after coronary artery stenting. The patient developed a pneumonia as a complication. He was admitted to the Intermediate Treatment Unit, receiving wide spectrum antimicrobial therapy and a granulocyte colony stimulating factor (Neupogen(r)) with favourable response. Ticlodipine is an effective antiplatelet agent, but has serious hematological and other side effects. Its prescription requires a close follow up and search for complications.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Bone Marrow Diseases / chemically induced*
  • Filgrastim
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / adverse effects*
  • Platelet Count
  • Recombinant Proteins
  • Ticlopidine / adverse effects*

Substances

  • Platelet Aggregation Inhibitors
  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • Ticlopidine
  • Filgrastim