Synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives: application in solution peptide synthesis

Molecules. 2010 Dec 20;15(12):9403-17. doi: 10.3390/molecules15129403.

Abstract

A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gave the corresponding N-triazinyl amino acid derivatives as a major product. The oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) uronium salt was superior to other uronium salts in terms of racemization, while 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT, 9) gave the best results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Peptides / chemical synthesis*
  • Peptides / chemistry*
  • Triazoles / chemistry

Substances

  • Peptides
  • Triazoles