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The GDF-5 mutant M1673 exerts robust anabolic and anti-catabolic effects in chondrocytes.
J Cell Mol Med. 2020 Jul;24(13):7141-7150. doi: 10.1111/jcmm.15149. Epub 2020 Jun 4.
J Cell Mol Med. 2020.
PMID: 32497388
Free PMC article.
BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.
Mang T, Kleinschmidt-Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A.
Mang T, et al.
J Cell Sci. 2020 Aug 21;133(16):jcs246934. doi: 10.1242/jcs.246934.
J Cell Sci. 2020.
PMID: 32764110
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Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5.
Mang T, Lindemann S, Gigout A.
Mang T, et al.
Int J Mol Sci. 2020 Jan 14;21(2):531. doi: 10.3390/ijms21020531.
Int J Mol Sci. 2020.
PMID: 31947660
Free PMC article.
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