Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds

Norbert Haider; Tamara Kabicher; Johann Käferböck; Angelika Plenk

doi:10.3390/12081900

Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds

Molecules. 2007 Aug 17;12(8):1900-9. doi: 10.3390/12081900.

Authors

Norbert Haider¹, Tamara Kabicher, Johann Käferböck, Angelika Plenk

Affiliation

¹ Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria. norbert.haider@univie.ac.at

Abstract

A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Catalysis
Indoles / chemical synthesis
Indoles / chemistry*
Indoles / pharmacology*
Palladium / chemistry
Phthalazines / chemical synthesis
Phthalazines / chemistry*
Phthalazines / pharmacology*

Substances

Antineoplastic Agents
Indoles
Phthalazines
Palladium