Tadashi Tokii - Search Results

Year	Number of Results
2010	2
2011	2
2013	1
2014	1
2018	1
2019	3
2020	1
2021	1
2024	0

1

Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells.

Okajima D, Yasuda S, Maejima T, Karibe T, Sakurai K, Aida T, Toki T, Yamaguchi J, Kitamura M, Kamei R, Fujitani T, Honda T, Shibutani T, Muramatsu S, Nakada T, Goto R, Takahashi S, Yamaguchi M, Hamada H, Noguchi Y, Murakami M, Abe Y, Agatsuma T. Okajima D, et al. Among authors: toki t. Mol Cancer Ther. 2021 Dec;20(12):2329-2340. doi: 10.1158/1535-7163.MCT-21-0206. Epub 2021 Aug 19. Mol Cancer Ther. 2021. PMID: 34413126 Free PMC article.

2

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.

Kawai J, Ota M, Ohki H, Toki T, Suzuki M, Shimada T, Matsui S, Inoue H, Sugihara C, Matsuhashi N, Matsui Y, Takaishi S, Nakayama K. Kawai J, et al. Among authors: toki t. ACS Med Chem Lett. 2019 May 24;10(6):893-898. doi: 10.1021/acsmedchemlett.9b00069. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223444 Free PMC article.

3

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.

Kawai J, Toki T, Ota M, Inoue H, Takata Y, Asahi T, Suzuki M, Shimada T, Ono K, Suzuki K, Takaishi S, Ohki H, Matsui S, Tsutsumi S, Hirota Y, Nakayama K. Kawai J, et al. Among authors: toki t. J Med Chem. 2019 Nov 27;62(22):10204-10220. doi: 10.1021/acs.jmedchem.9b01113. Epub 2019 Nov 18. J Med Chem. 2019. PMID: 31638799

4

Assessment of factors associated with completeness of spontaneous adverse event reporting in the United States: A comparison between consumer reports and healthcare professional reports.

Toki T, Ono S. Toki T, et al. J Clin Pharm Ther. 2020 Jun;45(3):462-469. doi: 10.1111/jcpt.13086. Epub 2019 Nov 25. J Clin Pharm Ther. 2020. PMID: 31765498 Free PMC article.

5

Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

Shimizu H, Tanaka S, Toki T, Yasumatsu I, Akimoto T, Morishita K, Yamasaki T, Yasukochi T, Iimura S. Shimizu H, et al. Among authors: toki t. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5113-8. doi: 10.1016/j.bmcl.2010.07.026. Epub 2010 Jul 13. Bioorg Med Chem Lett. 2010. PMID: 20675134

6

Spontaneous Reporting on Adverse Events by Consumers in the United States: An Analysis of the Food and Drug Administration Adverse Event Reporting System Database.

Toki T, Ono S. Toki T, et al. Drugs Real World Outcomes. 2018 Jun;5(2):117-128. doi: 10.1007/s40801-018-0134-0. Drugs Real World Outcomes. 2018. PMID: 29725886 Free PMC article.

7

Lipopolysaccharide accelerates collagen-induced arthritis in association with rapid and continuous production of inflammatory mediators and anti-type II collagen antibody.

Tanaka S, Toki T, Akimoto T, Morishita K. Tanaka S, et al. Among authors: toki t. Microbiol Immunol. 2013 Jun;57(6):445-54. doi: 10.1111/1348-0421.12052. Microbiol Immunol. 2013. PMID: 23773023 Free article.

8

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

Shimizu H, Yasumatsu I, Hamada T, Yoneda Y, Yamasaki T, Tanaka S, Toki T, Yokoyama M, Morishita K, Iimura S. Shimizu H, et al. Among authors: toki t. Bioorg Med Chem Lett. 2011 Feb 1;21(3):904-8. doi: 10.1016/j.bmcl.2010.12.078. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21232950

9

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

Shimizu H, Yamasaki T, Yoneda Y, Muro F, Hamada T, Yasukochi T, Tanaka S, Toki T, Yokoyama M, Morishita K, Iimura S. Shimizu H, et al. Among authors: toki t. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4550-5. doi: 10.1016/j.bmcl.2011.05.115. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21705219

10

A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.

Tanaka S, Toki T, Yokoyama M, Shimizu H, Yamasaki T, Yoneda Y, Muro F, Yasukochi T, Iimura S, Morishita K. Tanaka S, et al. Among authors: toki t. Biol Pharm Bull. 2014;37(1):87-95. doi: 10.1248/bpb.b13-00628. Biol Pharm Bull. 2014. PMID: 24389485 Free article.

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