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Page 1
Werner's syndrome.
Duvic M, Lemak NA. Duvic M, et al. Dermatol Clin. 1995 Jan;13(1):163-8. Dermatol Clin. 1995. PMID: 7712642 Review.
Werner's syndrome is a rare autosomal recessive disorder that affects connective tissue throughout the body. ...
Werner's syndrome is a rare autosomal recessive disorder that affects connective tissue throughout the body. ...
Research on Werner Syndrome: Trends from Past to Present and Future Prospects.
Tsuge K, Shimamoto A. Tsuge K, et al. Genes (Basel). 2022 Oct 6;13(10):1802. doi: 10.3390/genes13101802. Genes (Basel). 2022. PMID: 36292687 Free PMC article. Review.
A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is characterized by the early onset of aging-associated diseases, including shortening stature, alopecia, bilateral cataracts, skin ulcers, diabetes, osteoporosis, arteriosclerosis, and chromosom …
A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is characterized by the early onset of aging-associated …
Werner syndrome protein works as a dimer for unwinding and replication fork regression.
Shin S, Hyun K, Lee J, Joo D, Kulikowicz T, Bohr VA, Kim J, Hohng S. Shin S, et al. Nucleic Acids Res. 2023 Jan 11;51(1):337-348. doi: 10.1093/nar/gkac1200. Nucleic Acids Res. 2023. PMID: 36583333 Free PMC article.
We use single-molecule multi-color fluorescence imaging to determine the oligomeric states of Werner syndrome protein (WRN) during its unwinding and replication fork regression activities. ...
We use single-molecule multi-color fluorescence imaging to determine the oligomeric states of Werner syndrome protein (WRN) during it …
Werner syndrome in a Lebanese family.
Jaafar B, Nasrallah M, Sievers B, Oshima J, Lessel D. Jaafar B, et al. Am J Med Genet A. 2022 May;188(5):1630-1634. doi: 10.1002/ajmg.a.62654. Epub 2022 Jan 17. Am J Med Genet A. 2022. PMID: 35037378 Free PMC article.
Werner syndrome (WS) is an extremely rare, autosomal recessive segmental progeroid disorder caused by biallelic pathogenic variants in the WRN, which encodes a multifunctional nuclear protein that belongs to the RecQ family of DNA helicases. ...Here, we report a consanguin …
Werner syndrome (WS) is an extremely rare, autosomal recessive segmental progeroid disorder caused by biallelic pathogenic variants i …
Reduction of Werner Syndrome Protein Enhances G:C A:T Transition by O(6)-Methylguanine in Human Cells.
Suzuki T, Kuramoto Y, Kamiya H. Suzuki T, et al. Chem Res Toxicol. 2018 May 21;31(5):319-324. doi: 10.1021/acs.chemrestox.8b00009. Epub 2018 Apr 12. Chem Res Toxicol. 2018. PMID: 29616805
O(6)-Methylguanine ( O(6)-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-related human DNA helicase. ...The lowered amount of WRN increased the frequency of mutations induced by O(6)-MeG, mainly G:C A:T substit …
O(6)-Methylguanine ( O(6)-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-rela …
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases.
Lautrup S, Caponio D, Cheung HH, Piccoli C, Stevnsner T, Chan WY, Fang EF. Lautrup S, et al. Biogerontology. 2019 Jun;20(3):255-269. doi: 10.1007/s10522-019-09798-2. Epub 2019 Jan 21. Biogerontology. 2019. PMID: 30666569 Review.
Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend 'healthy aging' and the cure of human aging-related diseases. Werner syndrome (WS), is a heritable human premature aging disease caused by mutations in the g …
Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend 'healthy aging' and the …
Werner's syndrome T lymphocytes display a normal in vitro life-span.
James SE, Faragher RG, Burke JF, Shall S, Mayne LV. James SE, et al. Mech Ageing Dev. 2000 Dec 20;121(1-3):139-49. doi: 10.1016/s0047-6374(00)00205-0. Mech Ageing Dev. 2000. PMID: 11164468
Werner's syndrome (WS) is an autosomal recessive disorder displaying many features consistent with accelerated ageing. ...To test the hypothesis, WS T lymphocytes were cultured until they reached replicative senescence. ...
Werner's syndrome (WS) is an autosomal recessive disorder displaying many features consistent with accelerated ageing. ...To test the …
Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008).
Goto M, Ishikawa Y, Sugimoto M, Furuichi Y. Goto M, et al. Biosci Trends. 2013 Feb;7(1):13-22. Biosci Trends. 2013. PMID: 23524889 Free article. Review.
As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most case reports and clinical studies on WS has been published in Japanese journals. ...
As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most cas …
WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome.
Tian Y, Wang W, Lautrup S, Zhao H, Li X, Law PWN, Dinh ND, Fang EF, Cheung HH, Chan WY. Tian Y, et al. Nat Commun. 2022 Sep 16;13(1):5456. doi: 10.1038/s41467-022-33012-6. Nat Commun. 2022. PMID: 36114168 Free PMC article.
Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature aging due to mutations of the WRN gene. ...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature aging due to mutations of the WRN gene. ...
WRN mutations in Werner syndrome.
Moser MJ, Oshima J, Monnat RJ Jr. Moser MJ, et al. Hum Mutat. 1999;13(4):271-9. doi: 10.1002/(SICI)1098-1004(1999)13:4<271::AID-HUMU2>3.0.CO;2-Q. Hum Mutat. 1999. PMID: 10220139 Review.
Werner syndrome (WS) is one of a group of human genetic diseases that have recently been linked to deficits in cellular helicase function. ...
Werner syndrome (WS) is one of a group of human genetic diseases that have recently been linked to deficits in cellular helicase func …
10,608 results
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