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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1925 1
1931 1
1936 1
1945 2
1946 1
1948 1
1959 1
1961 1
1962 2
1963 3
1964 1
1966 1
1968 2
1969 4
1970 2
1971 4
1972 6
1973 7
1974 7
1975 127
1976 111
1977 124
1978 108
1979 105
1980 162
1981 255
1982 283
1983 367
1984 409
1985 357
1986 416
1987 708
1988 1123
1989 1197
1990 1362
1991 1417
1992 1414
1993 1402
1994 1501
1995 1543
1996 1546
1997 1560
1998 1618
1999 1751
2000 1837
2001 2049
2002 2172
2003 2275
2004 2523
2005 2496
2006 2227
2007 2458
2008 2612
2009 2585
2010 2865
2011 3106
2012 3183
2013 3636
2014 4868
2015 5808
2016 4555
2017 3631
2018 5501
2019 5648
2020 5980
2021 6496
2022 5978
2023 4789
2024 575

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100,112 results

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Page 1
AIM2 in regulatory T cells restrains autoimmune diseases.
Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. Chou WC, et al. Nature. 2021 Mar;591(7849):300-305. doi: 10.1038/s41586-021-03231-w. Epub 2021 Jan 27. Nature. 2021. PMID: 33505023 Free PMC article.
Here we show that the DNA-binding inflammasome receptor AIM2(7-10) has a T cell-intrinsic and inflammasome-independent role in the function of T regulatory (T(reg)) cells. AIM2 is highly expressed by both human and mouse T(reg) cells, is induced by TGF …
Here we show that the DNA-binding inflammasome receptor AIM2(7-10) has a T cell-intrinsic and inflammasome-independent role in the fu …
Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors.
Hirabayashi K, Du H, Xu Y, Shou P, Zhou X, Fucá G, Landoni E, Sun C, Chen Y, Savoldo B, Dotti G. Hirabayashi K, et al. Nat Cancer. 2021 Sep;2(9):904-918. doi: 10.1038/s43018-021-00244-2. Epub 2021 Sep 23. Nat Cancer. 2021. PMID: 34746799 Free PMC article.
Molecular and signaling studies indicate that T cells engineered with the proposed CAR design demonstrate sustained phosphorylation of T cell receptor-associated (TCR) signaling molecules and a molecular signature supporting CAR-T cell proliferation and long- …
Molecular and signaling studies indicate that T cells engineered with the proposed CAR design demonstrate sustained phosphorylation o …
Interleukin-23 engineering improves CAR T cell function in solid tumors.
Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Porterfield Kren N, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. Ma X, et al. Nat Biotechnol. 2020 Apr;38(4):448-459. doi: 10.1038/s41587-019-0398-2. Epub 2020 Feb 3. Nat Biotechnol. 2020. PMID: 32015548 Free PMC article.
However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cytokine known to promote proliferation of memory T cells and T helper type 17 cells. ...In two xenograft and two syngeneic solid …
However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cyto …
Epidemiology of osteoarthritis.
Allen KD, Thoma LM, Golightly YM. Allen KD, et al. Osteoarthritis Cartilage. 2022 Feb;30(2):184-195. doi: 10.1016/j.joca.2021.04.020. Epub 2021 Sep 14. Osteoarthritis Cartilage. 2022. PMID: 34534661 Free PMC article. Review.
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
Xu N, Palmer DC, Robeson AC, Shou P, Bommiasamy H, Laurie SJ, Willis C, Dotti G, Vincent BG, Restifo NP, Serody JS. Xu N, et al. J Exp Med. 2021 Feb 1;218(2):e20200844. doi: 10.1084/jem.20200844. J Exp Med. 2021. PMID: 33382402 Free PMC article.
CAR T cells generated from Th/Tc17 cells given with the STING agonists DMXAA or cGAMP greatly enhanced tumor control, which was associated with enhanced CAR T cell persistence in the TME. ...However, sustained tumor regression was accomplished only with the addition …
CAR T cells generated from Th/Tc17 cells given with the STING agonists DMXAA or cGAMP greatly enhanced tumor control, which was assoc …
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer.
Hollern DP, Xu N, Thennavan A, Glodowski C, Garcia-Recio S, Mott KR, He X, Garay JP, Carey-Ewend K, Marron D, Ford J, Liu S, Vick SC, Martin M, Parker JS, Vincent BG, Serody JS, Perou CM. Hollern DP, et al. Cell. 2019 Nov 14;179(5):1191-1206.e21. doi: 10.1016/j.cell.2019.10.028. Cell. 2019. PMID: 31730857 Free PMC article.
Using this, we uncover that immune checkpoint therapy induces T follicular helper cell activation of B cells to facilitate the anti-tumor response in these models. We also show that B cell activation of T cells and the generation of antibody are key to immunotherapy …
Using this, we uncover that immune checkpoint therapy induces T follicular helper cell activation of B cells to facilitate the anti-t …
Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration.
Li H, Harrison EB, Li H, Hirabayashi K, Chen J, Li QX, Gunn J, Weiss J, Savoldo B, Parker JS, Pecot CV, Dotti G, Du H. Li H, et al. Nat Commun. 2022 Apr 20;13(1):2154. doi: 10.1038/s41467-022-29647-0. Nat Commun. 2022. PMID: 35443752 Free PMC article.
The co-expression of the CCL2 receptor CCR2b in B7-H3.CAR-T cells, significantly improves their capability of passing the BBB, providing enhanced antitumor activity against brain tumor lesions. These findings indicate that leveraging T-cell chemotaxis through CCR2b …
The co-expression of the CCL2 receptor CCR2b in B7-H3.CAR-T cells, significantly improves their capability of passing the BBB, provid …
Multi-omics analyses reveal that HIV-1 alters CD4(+) T cell immunometabolism to fuel virus replication.
Guo H, Wang Q, Ghneim K, Wang L, Rampanelli E, Holley-Guthrie E, Cheng L, Garrido C, Margolis DM, Eller LA, Robb ML, Sekaly RP, Chen X, Su L, Ting JP. Guo H, et al. Nat Immunol. 2021 Apr;22(4):423-433. doi: 10.1038/s41590-021-00898-1. Epub 2021 Mar 25. Nat Immunol. 2021. PMID: 33767427 Free PMC article.
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4(+) T cells through unclear mechanisms with undefined consequences. ...This study uncovers the OXPHOS pathway in CD4(+) T cells as a target for HIV-1 therapy....
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4(+) T cells through unclear me …
A multi-omic single-cell landscape of human gynecologic malignancies.
Regner MJ, Wisniewska K, Garcia-Recio S, Thennavan A, Mendez-Giraldez R, Malladi VS, Hawkins G, Parker JS, Perou CM, Bae-Jump VL, Franco HL. Regner MJ, et al. Mol Cell. 2021 Dec 2;81(23):4924-4941.e10. doi: 10.1016/j.molcel.2021.10.013. Epub 2021 Nov 4. Mol Cell. 2021. PMID: 34739872 Free PMC article.
A comparison of SRK/T formula with Hill RBF 2 and Barrett Universal II in the calculation of intraocular lens power.
Malik TG, Moin M, Alam R. Malik TG, et al. J Pak Med Assoc. 2022 Jul;72(7):1373-1377. doi: 10.47391/JPMA.3842. J Pak Med Assoc. 2022. PMID: 36156563 Free article.
OBJECTIVE: To compare the accuracy of SRK/T, Barrett Universal II and Hill radial basis activation function-2 formulas in intraocular lens power calculation using different axial lengths. ...In group 3, mean axial length was 21.74mm, with anterior chamber depth of 3 …
OBJECTIVE: To compare the accuracy of SRK/T, Barrett Universal II and Hill radial basis activation function-2 formulas in intr …
100,112 results
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