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A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions.
Ganesan A, Arulraj T, Choulli T, Barakat KH. Ganesan A, et al. BMC Med Inform Decis Mak. 2018 Jun 11;18(1):37. doi: 10.1186/s12911-018-0606-x. BMC Med Inform Decis Mak. 2018. PMID: 29890992 Free PMC article.
BACKGROUND: Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of anti-cancer therapy for the last few years. The human T-cell-based immune responses are modulated by two contradicting signals. ...
BACKGROUND: Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of an …
Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function.
Choul-Li S, Leroy C, Leprivier G, Laitem C, Tulasne D, Aumercier M. Choul-Li S, et al. Biochem J. 2010 Feb 9;426(2):229-41. doi: 10.1042/BJ20090877. Biochem J. 2010. PMID: 20001963
In the present study, we have demonstrated that Ets-1 p51, but not the spliced variant Ets-1 p42, is processed in a caspase-dependent manner in Jurkat T-leukaemia cells undergoing apoptosis, resulting in three C-terminal fragments Cp20, Cp17 and Cp14 and a N-terminal fragm …
In the present study, we have demonstrated that Ets-1 p51, but not the spliced variant Ets-1 p42, is processed in a caspase-dependent manner …
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