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Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways.
Zolotovskaia MA, Modestov AA, Suntsova MV, Rachkova AA, Koroleva EV, Poddubskaya EV, Sekacheva MI, Tkachev VS, Garazha AV, Glusker AA, Seryakov AP, Vladimirova US, Rumiantsev PO, Moisseev AA, Zharkov DO, Kuzmin DV, Zhao X, Prassolov VS, Shegay PV, Li X, Steinbichler TB, Kim E, Sorokin MI, Wang Y, Buzdin AA. Zolotovskaia MA, et al. DNA Repair (Amst). 2023 Mar;123:103448. doi: 10.1016/j.dnarep.2023.103448. Epub 2023 Jan 13. DNA Repair (Amst). 2023. PMID: 36657260
At the DNA level, we found that ATM, TP53, and CDKN1A genes accumulated loss of function mutations, and cyclin B complex genes - transforming mutations. These findings suggest importance of activation for most of DNA repair pathways in cancer progression, with remarkable e …
At the DNA level, we found that ATM, TP53, and CDKN1A genes accumulated loss of function mutations, and cyclin B complex genes - tran …
Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction.
Greier MDC, Runge A, Dudas J, Hartl R, Santer M, Dejaco D, Steinbichler TB, Federspiel J, Seifarth C, Konschake M, Sprung S, Sopper S, Randhawa A, Mayr M, Hofauer BG, Riechelmann H. Greier MDC, et al. Front Oncol. 2024 Mar 7;14:1364577. doi: 10.3389/fonc.2024.1364577. eCollection 2024. Front Oncol. 2024. PMID: 38515569 Free PMC article.
Granzyme B was measured in the supernatant and in the SC via immunohistochemistry (IHC). ...Moreover, high glucose concentration did not promote cytotoxic T cell activity in HNSCC SC....
Granzyme B was measured in the supernatant and in the SC via immunohistochemistry (IHC). ...Moreover, high glucose concentration did …