EHPG iron(III) complexes as potential contrast contrast agents for MRI

Acta Chim Slov. 2014;61(1):87-93.

Abstract

A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHAc and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T1), EPR and cyclic voltammetry (CV). r1 Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Electron Spin Resonance Spectroscopy
  • Ethylenediamines / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Iron / chemistry*
  • Magnetic Resonance Imaging*
  • Organometallic Compounds / chemistry*

Substances

  • Contrast Media
  • Ethylenediamines
  • Organometallic Compounds
  • ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid)
  • Iron