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The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, Nübel U, Bartel J, Kany AM, Zühlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, Müller R, Fuchs TM, Strowig T. Bublitz A, et al. Among authors: bernecker s. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. doi: 10.1016/j.chom.2023.04.003. Epub 2023 Apr 24. Cell Host Microbe. 2023. PMID: 37098342 Free article.
Pinensins: the first antifungal lantibiotics.
Mohr KI, Volz C, Jansen R, Wray V, Hoffmann J, Bernecker S, Wink J, Gerth K, Stadler M, Müller R. Mohr KI, et al. Among authors: bernecker s. Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11254-8. doi: 10.1002/anie.201500927. Epub 2015 Jul 24. Angew Chem Int Ed Engl. 2015. PMID: 26211520
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives.
Hofer W, Oueis E, Fayad AA, Deschner F, Andreas A, de Carvalho LP, Hüttel S, Bernecker S, Pätzold L, Morgenstern B, Zaburannyi N, Bischoff M, Stadler M, Held J, Herrmann J, Müller R. Hofer W, et al. Among authors: bernecker s. Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202202816. doi: 10.1002/anie.202202816. Epub 2022 Jun 13. Angew Chem Int Ed Engl. 2022. PMID: 35485800 Free PMC article.
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application.
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany AM, Große M, Stadler M, Bischoff M, Hirsch AKH, Held J, Herrmann J, Müller R. Hofer W, et al. Among authors: bernecker s. Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319765. doi: 10.1002/anie.202319765. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38502093
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežič T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, Imirzalioglu C, Vogel J, Westermann AJ, Hesterkamp T, Stadler M, Wagenlehner F, Petković H, Herrmann J, Müller R. Hennessen F, et al. Among authors: bernecker s. Antibiotics (Basel). 2020 Sep 18;9(9):619. doi: 10.3390/antibiotics9090619. Antibiotics (Basel). 2020. PMID: 32962088 Free PMC article.
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