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Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process.
Alessio N, Riccitiello F, Squillaro T, Capasso S, Del Gaudio S, Di Bernardo G, Cipollaro M, Melone MAB, Peluso G, Galderisi U. Alessio N, et al. Among authors: capasso s. Exp Mol Med. 2018 Mar 22;50(3):1. doi: 10.1038/s12276-017-0005-x. Exp Mol Med. 2018. PMID: 29563495 Free PMC article.
Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect.
Zanichelli F, Capasso S, Cipollaro M, Pagnotta E, Cartenì M, Casale F, Iori R, Galderisi U. Zanichelli F, et al. Among authors: capasso s. Age (Dordr). 2012 Apr;34(2):281-93. doi: 10.1007/s11357-011-9231-7. Epub 2011 Apr 6. Age (Dordr). 2012. PMID: 21465338 Free PMC article.