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Zebrafish as model system for the biological characterization of CK1 inhibitors.
Meier L, Gahr BM, Roth A, Gihring A, Kirschner S, Woitaske-Proske C, Baier J, Peifer C, Just S, Knippschild U. Meier L, et al. Among authors: kirschner s. Front Pharmacol. 2023 Sep 11;14:1245246. doi: 10.3389/fphar.2023.1245246. eCollection 2023. Front Pharmacol. 2023. PMID: 37753113 Free PMC article.
C5-Iminosugar modification of casein kinase 1δ lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity.
von Drathen T, Ure EM, Kirschner S, Roth A, Meier L, Woolhouse AD, Cameron SA, Knippschild U, Peifer C, Luxenburger A. von Drathen T, et al. Among authors: kirschner s. Arch Pharm (Weinheim). 2022 May;355(5):e2100497. doi: 10.1002/ardp.202100497. Epub 2022 Feb 17. Arch Pharm (Weinheim). 2022. PMID: 35174898