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Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.
Scholz O, Huß E, Otter S, Herebian D, Hamacher A, Levy LM, Hristeva S, Sanz M, Ajani H, Puentes AR, Hoffmann T, Hogeback J, Unger A, Terheyden S, Reina do Fundo M, Dewidar B, Roden M, Lammert E. Scholz O, et al. Among authors: hristeva s. Mol Metab. 2023 Sep;75:101775. doi: 10.1016/j.molmet.2023.101775. Epub 2023 Jul 12. Mol Metab. 2023. PMID: 37451343 Free PMC article.
Interrogating dense ligand chemical space with a forward-synthetic library.
Chevillard F, Stotani S, Karawajczyk A, Hristeva S, Pardon E, Steyaert J, Tzalis D, Kolb P. Chevillard F, et al. Among authors: hristeva s. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11496-11501. doi: 10.1073/pnas.1818718116. Epub 2019 May 21. Proc Natl Acad Sci U S A. 2019. PMID: 31113876 Free PMC article.
Set-up and screening of a fragment library targeting the 14-3-3 protein interface.
Valenti D, Neves JF, Cantrelle FX, Hristeva S, Lentini Santo D, Obšil T, Hanoulle X, Levy LM, Tzalis D, Landrieu I, Ottmann C. Valenti D, et al. Among authors: hristeva s. Medchemcomm. 2019 Jul 22;10(10):1796-1802. doi: 10.1039/c9md00215d. eCollection 2019 Oct 1. Medchemcomm. 2019. PMID: 31814953 Free PMC article.
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach.
Wolter M, Valenti D, Cossar PJ, Hristeva S, Levy LM, Genski T, Hoffmann T, Brunsveld L, Tzalis D, Ottmann C. Wolter M, et al. Among authors: hristeva s. J Med Chem. 2021 Jun 24;64(12):8423-8436. doi: 10.1021/acs.jmedchem.1c00401. Epub 2021 Jun 2. J Med Chem. 2021. PMID: 34076416 Free PMC article.